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Upcoming Speaker:
December 19, 2018
A Case Study in Computational Mass Spectrometry
An invitation: If you are interested in presenting your work to our diverse audience of informaticists; basic, translational, and clinical researchers; software developers; and others interested in exploring the uses of informatics in cancer research, contact Eve Shalley at eve.shalley@nih.gov or 240-276-5194.
Welcome to the CBIIT Speaker Series Wiki
The NCI Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series presents talks from innovators in the research and informatics community. The biweekly presentations allow thought leaders to share their work and discuss trends across a diverse set of domains and interests. The goals of the Speaker Series are: to share leading edge research; to inform the community of new tools, trends, and ideas; to inspire innovation; and to provide a forum from which new collaborations can begin.
Speakers represent many different institutions, and the topics they address are wide-ranging. View a list of all past speakers, and view their presentations on our NCI CBIIT Speaker Series YouTube playlist!
For help accessing NCI CBIIT Speaker Series files, go to Help Downloading Files.
Location: 9609 Medical Center Drive, Rockville, Maryland 20850
Speaker Series Guidelines for Speakers: Download Word document
Questions or suggestions? If you have questions or would like to recommend a speaker, please email Eve Shalley at eve.shalley@nih.gov
Please refer to the Speaker Calendar below for upcoming speakers.
Upcoming Speakers:
December 19, 2018: Rob Smith, University of Montana
January 16, 2019: Chunlei Wu, The Scripps Institute
January 30, 2019: Gil Alterovitz, Harvard/MIT Health Services
February 13, 2019: Kenneth Gersing, National Center for Advancing Translational Sciences (NCATS), NIH
February 27, 2019: Thomas Klumpp, Thomas Jefferson University Medical Center
March 27, 2019: Samir Courdy, Huntsman Cancer Institute, and Joyce Niland, City of Hope
CBIIT Speakers
This talk will discuss the role, effect, and quality of informatics in publicly funded research, from selection of proposals for funding to execution and sustainment. The case will be made that many current funding mechanisms are mismatched to the scope, needs, and impact of informatics research by comparing and contrasting informatics projects with traditional experimental R&D proposals. Causes for poor quality informatics projects will be enumerated and suggestions given to address them.
Definite diagnosis of cancer presence or recurrence is currently only possible via invasive biopsy or surgical intervention. Unfortunately, invasive biopsy, (a) in many cases is unnecessary due to absence of the disease, (b) have sampling errors depending on where the tissue sample is acquired from, and (c) could have irreparable and life-threatening side effects including mortality. Recently, artificial intelligence and radiomics have shown tremendous promise in leveraging imaging to non-invasively capture the landscape of tissue heterogeneity, previously not feasible by visual inspection. Similarly, one would leverage -omics and pathology information in conjunction with routine imaging to establish cross-scale associations towards designing more optimized personalized treatment options for cancer treatment.
In this talk, I will focus on my lab’s recent efforts in developing radiomic (extracting computerized sub-visual features from radiologic imaging), radio-genomic (identifying radiologic features associated with molecular phenotypes), and radio-pathomic (radiologic features associated with pathologic phenotypes) techniques to capture insights into the underlying tumor biology as observed on non-invasive routine imaging. I will focus on clinical applications of this work for predicting disease outcome, recurrence, progression and response to therapy specifically in the context of brain tumors. I will also discuss our current efforts in developing new radiomic features for post-treatment evaluation and predicting response to chemo-radiation treatment. I will conclude with a discussion on our recent findings in AI + experts, in the context of a clinically challenging problem of distinguishing benign radiation effects from tumor recurrence on routine MRI scans.
This special 90-minute session of the CBIIT Speaker Series will feature demos of three tools that were developed through funding by the Informatics Technology for Cancer Research (ITCR) Program.
- Jim Robinson from UCSD and Helga Thorvaldsdottir from the Broad Institute will present the Integrative Genomics Viewer
- Mary Goldman from UC Santa Cruz will present the Xena Functional Genomics Browser
- Alexander Krasnitz from Cold Spring Harbor Lab will present the Single Cell Genome Viewer
Cancer patients and their doctors choose from a range of different treatment options. But often the chosen treatment is ineffective, reducing quality and length of life and increasing cost. Today treatment decisions and outcomes occur in isolation. All4Cure has built a patient-centered, web-based, knowledge sharing platform that graphically portrays treatments and responses extracted from the medical records of de-identified patients with multiple myeloma (the second most common form of blood cancer) for comment by a community of participating patients, clinicians and researchers. Having assembled more than 580 participants we will describe examples of patients have benefited from their participation.