July 19: Angel Pizarro, Scientific Computing at Amazon Web Services
October 11: Anant Madabhushi, Case Western Reserve University
November 8: Hugo Aerts, Dana Farber Cancer Center / Harvard Medical School
Modern information systems, storage devices and recording formats have led to unprecedented growths in scientific and social data. These advancements have resulted in the Big Data (BD) paradigm – enormous data collection for processing and analyses that can provide new information not otherwise gleaned from smaller disparate data collections.
This presentation will discuss the Open Archival Information System (OAIS) reference model, to address challenges posed by BD. Examples from Earth Observing Systems and Biomedical research systems will be shown to elucidate the OAIS. An integrated reference architecture for BD life cycle management will be presented.
Intelligent biomedical archives (IBA) concept and characteristics that differentiate IBA from traditional archives will be highlighted. A functional view of the IBA will be presented for increasing transformation of data to knowledge. Scenario-based examples from biomedical research will be provided to stimulate discussion on approaches to operationalize IBA. A vision for developing true knowledge building systems for biomedical research will be shared.
This session will address the role of computer-aided diagnosis and machine learning in the practice of radiology. The debate format will address the question of whether computers will replace radiologists in 20 years. The session will include information on state-of-the-art machine learning methods, computer-aided diagnosis results, and prognostications on these tools. Impediments to computers replacing radiologists will also be described.
Pediatric cancers are the leading cause of disease-related death in children, but are defined as a rare disease when contrasted to adult tumors. Because of this classification, pediatric cancer discovery efforts are challenging due to a more limited basic and translational data-driven research infrastructure. As such, harnessing the potential for accelerated discovery through large-scale molecular/genomic data-generation and analysis platforms requires new approaches and tools for collaborative discovery on behalf of the rare disease patient-community. The Children’s Hospital of Philadelphia and its partnered consortia-based institutions have piloted a series of data-focused initiatives which span biospecimen-driven pediatric cancer research, clinical trials, data storage, analysis, and visualization platform-development. Covered in the presentation will be our experiences over the past five years in these efforts and the partnered development of CAVATICA, a data analysis platform designed to both facilitate the rapid integration and analysis of genomic data from multiple diseases affecting children and enable transdisciplinary discovery via interoperability with the Genomic Data Commons and other NIH data repositories.
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