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Note: These collections have been migrated to The Cancer Imaging Archive (TCIA) with the exception of RIDER Pilot. Visit the TCIA RIDER Collections wiki page to learn more.

Summary

The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):

All the image data are DICOM compliant and the image, annotations and meta data formats meets all the requirements for caBIG and the NBIA.  The data collection has two phases as described below, which have resulted in several distinct image Collections.

RIDER Pilot (2005-2007)

This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated.

Pilot Statistics

Value

Modalities

CT, DX

Number of Patients

322

Number of Studies

1,779

Number of Series

4,930

Number of Images

384,535

RIDER Contracts (2007-Beyond)

NCI has exercised a series of contracts with specific academic sites for collection of repeat "coffee break" and longitudinal phantom and patient data for a range of imaging modalities (currently CT, PET CT, DCE MRI, DW MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:

  1. Develop a consensus on requirements for quantity assurance methods for longitudinal studies using phantom data as applied to each modality above,
  2. Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised,
  3. Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies
  4. Provide access to results of measurements performed on these databases by each academic site to encourage a comparison on methodologies,
  5. Provide consensus-based juried publications to encourage a broad acceptance of the methods described above.
  6. Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network QIN):  http://grants.nih.gov/grants/guide/pa-files/PAR-11.150.html


The databases are being provided with a timely goal of 18 months time frame, namely from the time the contract was initiated and the published results within less than 2 years. The methods for data collection and analysis including results are described in the new Combined RIDER white Paper Report (Sept 2008): RIDER White Paper: Combined contracts report ( Sept 2008)

The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html

ACADEMIC SITE COLLECTIONS: Focus on methods for data analysis

MSKCC

Lung CT Statistics

Value

Modalities

CT

Number of Patients

32

Number of Studies

46

Number of Series

64

Number of Images

15,716

UNIVERSITY OF WASHINGTON

  • Images contained in "Phantom" Collection
  • Repeat measurements: PET/CT phantoms

Collection Statistics

Value

Modalities

CT, PT

Number of Patients

20

Number of Studies

20

Number of Series

60

Number of Images

2,231

  • Images contained in "RIDER Lung PET CT" Collection
  • Longitudinal PET/CT human studies: Lung

Lung PET CT Statistics

Value

Modalities

CT, PT

Number of Patients

244

Number of Studies

275

Number of Series

1349

Number of Images

269,522

DUKE UNIVERSITY

  • Images contained in "RIDER Neuro MRI" Collection
  • Repeat human subject studies: Neuro
  • Dynamic Contract Enhanced studies: DCE MRI:
  • Diffusion weighted imaging: DWI MR
  • Diffusion tensor imaging: DT MRI.

Neuro MRI Statistics

Value

Modalities

MR

Number of Patients

19

Number of Studies

108

Number of Series

368

Number of Images

70,220

UNIVERSITY OF MICHIGAN

  • Images contained in "RIDER Breast MRI" Collection
  • Repeat measurements: Human subjects: Breast
  • DCE MRI
  • ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.

Breast MRI Statistics

Value

Modalities

MR

Number of Patients

5

Number of Studies

10

Number of Series

40

Number of Images

2,400

MDACC

  • Images contained in "RIDER Phantom MRI" Collection
  • Repeat measurement: Phantom studies
  • DCE MRI
  • RIDER_MR_Phantom_Data_Summary provides a summary of the images in this collection.

  • RIDER_PhantomMR_Key provides a key for understanding their presentation in NBIA.

Phantom MRI Statistics

Value

Modalities

MR

Number of Patients

10

Number of Studies

13

Number of Series

45

Number of Images

7,061

ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection

MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)

SOCIETY DATA COLLECTIONS

RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)

OTHER FEDERAL AGENCIES

FDA CDRH: Partly funded by NCI and NIBIB

NIST

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