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Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 50,000 out of the 120,000 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (11.09d: September 2011)
chart showing NCIt concepts with terms from tagged outside sources

NCIt concepts with tagged synonyms from each outside source (13.03d: March 2013)

NCIt Concepts

Source

335

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

25

ZFin

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908: August 2019)

NCIm concepts

Source Label - NCIt-derived

Source Name

1149 BRIDG_3_0_3Biomedical Research   Integrated Domain Group Model, 3.0.3, 2019_07E
20 BRIDGBiomedical Research   Integrated Domain Group Model, 2019_07E
334

BioC

BioCarta online maps of molecular pathways, adapted for NCI use, 2019_07E

407
CARELEXContent Archive   Resource Exchange Lexicon, 2019_07E
40
CBDDChemical Biology and Drug Development Vocabulary, 2019_07E
923

CDC

U.S. Centers for   Disease Control and Prevention, 2019_07E
714
CDISC-GLOSSClinical Data   Interchange Standards Consortium Glossary Terms, 2019_07E
21313

CDISC

Clinical Data   Interchange Standards Consortium, 2019_07E
3657

CPTAC

Clinical Proteomic   Tumor Analysis Consortium, 2019_07E
406

CRCH

Cancer Research   Center of Hawaii Nutrition Terminology, 2019_07E
5599
CTCAE_3Common Terminology   Criteria for Adverse Events 3.0, 2019_07E
4022
CTCAE_5Common Terminology   Criteria for Adverse Events 5.0, 2019_07E
770CTCAECommon Terminology   Criteria for Adverse Events, 2019_07E
373CTEP-SDCCancer Therapy   Evaluation Program - Simple Disease Classification, 2019_07E
21343

CTRP

Clinical Trials   Reporting Program, 2019_07E
903

DCP

NCI Division of   Cancer Prevention Program, 2019_07E
114

DICOM

Digital Imaging   Communications in Medicine, 2019_07E
694

DTP

NCI Developmental   Therapeutics Program, 2019_07E
1009EDQM-HCEuropean   Directorate for the Quality of Medicines & Healthcare, 2019_07E
21857

FDA

U.S. Food and Drug   Administration, 2019_07E
207GAIAGlobal Alignment of   Immunization Safety Assessment in pregnancy, 2019_07E
281

GENC

Geopolitical   Entities, Names, and Codes Standard, 2019_07E
215

ICH

International   Conference on Harmonization, 2019_07E
201 INCInternational Neonatal Consortium, 2019_07E
156 JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2019_07E
244 KEGGKEGG Pathway Database, 2019_07E
5077 NCI-GLOSSNCI Dictionary of Cancer Terms, 2019_07E
5001 NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2019_07E
129 NCI-HL7NCI Health Level 7, 2019_07E
146328NCINational Cancer Institute Thesaurus, 2019_07E
540 NCPDPNational Council for Prescription Drug Programs, 2019_07E
NDCNational Drug Code,   2019_07E
4782 NICHDNational Institute   of Child Health and Human Development, 2019_07E
39 PI-RADSProstate Imaging   Reporting and Data System, 2019_07E
169 PIDNational Cancer   Institute Nature Pathway Interaction Database, 2019_07E
310 RENIRegistry   Nomenclature Information System, 2019_07E
1361 UCUMUnified Code for   Units of Measure, 2019_07E
 25ZFINZebrafish Model   Organism Database, 2019_07E

NCIm concepts

Source Label - Other

Source Name

15,873

AOD

Alcohol and Other Drug Thesaurus, 2000

276

AOT

Authorized Osteopathic Thesaurus, 2003

13,255

CBO

Clinical Bioinformatics Ontology, 2011_02

622

CCS

Clinical Classifications Software, 2005

3,080

COSTAR

COSTAR, 1989-1995

16,501

CSP

CRISP Thesaurus, 2006

3,843

CST

COSTART, 1995

318

CTEP

Cancer Therapy Evaluation Program, 2004

435

CVX

Vaccines   Administered, 2018_10_18, 2019_03_04
7,711

DRUGBANK

DrugBank,   5.0_2016_06_22, 5.0_2019_01_31
7,293

DXP

DXplain, 1994
102,404

FMA

Foundational Model   of Anatomy Ontology, 4_10
7,503

GARD

Genetic and Rare   Diseases Information Center, 2015_04
70,289

GO

Gene Ontology,   2018_05_20
6,655

HCPCS

Healthcare Common   Procedure Coding System, 2019
41,301

HGNC

HUGO Gene   Nomenclature Committee, 2018_03
9,789
HL7V3.0HL7 Vocabulary   Version 3.0, 2018_08
15,301

HPO

Human Phenotype   Ontology, 2018_11_08
102,167ICD10CMInternational   Classification of Diseases, 10th Edition, Clinical Modification, 2019
190,389ICD10PCSICD-10-PCS, 2019
17,425ICD10ICD10, 2016
20,941ICD9CMInternational   Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2,588

ICDO

International   Classification of Disease for Oncology, 3_1
748

ICPC

International   Classification of Primary Care, 1993
5,057
ISO3166-2International   Organization for Standardization 3166-2, 2012
146,331

LNC

LOINC, 265
41

MCM

McMaster University   Epidemiology Terms, 1992
332
MDBCACMitelman Database   of Chromosome Aberrations in Cancer, 2005_12
56,014

MDR

Medical Dictionary   for Regulatory Activities Terminology (MedDRA), 22.0
3,315
MED-RTMedication   Reference Terminology, 2019_03_04
2,119
MEDLINEPLUSMedlinePlus Health   Topics, 20181108
900

MGED

MGED Ontology, 131
373,575  MSHMedical Subject Headings, 2019_2019_01_07
9

MTHCMSFRF

Metathesaurus CMS Formulary Reference File, MTHCMSFRF_2014

521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021

MTHICD9

International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014

1,633

MTHMST

Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001

58,600

MTHSPL

Metathesaurus FDA Structured Product Labels, 2019_02_22

194,860

MTH

UMLS Metathesaurus, 2019AA

76

MVX

Manufacturers of Vaccines, 2018_08_31

 1,409,501 NCBINCBI Taxonomy,   2018_04_19
 5,749NCIMTHNCIMTH
NCISEERNCI SEER ICD   Neoplasm Code Mappings, 1999
NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05
NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_05
39,434 NDFRTNational Drug File,   2018_02_05
1,887  NPONPO: NanoParticle   Ontology for Cancer Nanotechnology Research, 2011_12_08
106,313

OMIM

Online Mendelian   Inheritance in Man, 2019_02_04
12,399

PDQ

Physician Data   Query, 2016_07_31
2,039

PMA

Portfolio   Management Application, 2010
260

PNDS

Perioperative   Nursing Data Set, 4_2018
940

QMR

Quick Medical   Reference (QMR), 1996
45,733

RADLEX

RadLex, 3_15
201,450
RXNORMRxNorm Vocabulary,   18AB_190304F
347030SNOMEDCT_USUS Edition of   SNOMED CT, 2019_03_01
162

SOP

Source of Payment   Typology, 8
4,810

SPN

Standard Product   Nomenclature, 2003
200

SRC

Metathesaurus   Source Terminology Names
27,283

UMD

UMDNS: product   category thesaurus, 2019
 1,693 USPMGUSP Medicare Model   Guidelines, 2017
 4,352 USPUSP Compendial   Nomenclature, 2018_12_10
61,112

UWDA

University of   Washington Digital Anatomist, 1.7.3
34,194

VANDF

Veterans Health   Administration National Drug File, 2019_02_01

Overall Counts (August 2019)

ConceptsRelationships Attributes Total Number of Terms
3,265,686

22,852,144

 25,184,657 7,508,907



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