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Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 50,000 out of the 120,000 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (11.09d: September 2011)
chart showing NCIt concepts with terms from tagged outside sources

NCIt concepts with tagged synonyms from each outside source (13.03d: March 2013)

NCIt Concepts

Source

335

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

25

ZFin

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201105: May 2011)

NCIm concepts

Source Label - NCIt-derived

Source Name

334

BioC

BioCarta online maps of molecular pathways, adapted for NCI use, 1105E

1,139

BRIDG

Biomedical Research Integrated Domain Group Model, 1105E

921

CDC

U.S. Centers for Disease Control and Prevention, 1105E

5,636

CDISC

Clinical Data Interchange Standards Consortium, 1105E

406

CRCH

Cancer Research Center of Hawaii Nutrition Terminology, 1105E

6,368

CTCAE

Common Terminology Criteria for Adverse Events, 1105E

903

DCP

NCI Division of Cancer Prevention Program, 1105E

114

DICOM

Digital Imaging Communications in Medicine, 1105E

693

DTP

NCI Developmental Therapeutics Program, 1105E

15,471

FDA

U.S. Food and Drug Administration, 1105E

215

ICH

International Conference on Harmonization, 1105E

156

JAX

Jackson Laboratories Mouse Terminology, adapted for NCI use, 1105E

244

KEGG

KEGG Pathway Database, 1105E

85,314

NCI

National Cancer Institute Thesaurus, 2011_05E

5,084

NCI-GLOSS

NCI Dictionary of Cancer Terms, 1105E

125

NCI-HL7

NCI Health Level 7, 1105E

514

NCPDP

National Council for Prescription Drug Programs, 1105E

715

NICHD

National Institute of Child Health and Human Development, 1105E

169

PID

National Cancer Institute Nature Pathway Interaction Database, 1105E

310

RENI

Registry Nomenclature Information System, 1105E

287

UCUM

Unified Code for Units of Measure, 1105E

25

ZFIN

Zebrafish Model Organism Database, 1105E

NCIm concepts

Source Label - Other

Source Name

15,870

AOD

Alcohol and Other Drug Thesaurus, 2000

278

AOT

Authorized Osteopathic Thesaurus, 2003

13,255

CBO

Clinical Bioinformatics Ontology, 2011_02

1,104

CCS

Clinical Classifications Software, 2005

3,073

COSTAR

COSTAR, 1989-1995

16,572

CSP

CRISP Thesaurus, 2006

3,836

CST

COSTART, 1995

345

CTEP

Cancer Therapy Evaluation Program, 2004

7,278

DXP

DXplain, 1994

77,923

FMA

Foundational Model of Anatomy Ontology, 2_0

54,439

GO

Gene Ontology, 2010_04_01

5,602

HCPCS

Healthcare Common Procedure Coding System, 2010

7,483

HL7V3.0

HL7 Vocabulary Version 3.0, 2006_05

29,335

HUGO

HUGO Gene Nomenclature, 2010_05

11,532

ICD10

ICD10, 1998

1,004

ICD10AE

ICD10, American English Equivalents, 1998

97,631

ICD10CM

International Classification of Diseases, 10th Edition, Clinical Modification, 2010_03

181,116

ICD10PCS

ICD-10-PCS, 2009

20,779

ICD9CM

International Classification of Diseases, Ninth Revision, Clinical Modification, 2011

2,466

ICDO

International Classification of Diseases for Oncology, 3rd Edition, 2000

748

ICPC

International Classification of Primary Care, 1993

37,923

ICPC2ICD10ENG

ICPC2 - ICD10 Thesaurus, 200412

80,206

LNC

Logical Observation Identifier Names and Codes, 232

41

MCM

McMaster University Epidemiology Terms, 1992

331

MDBCAC

Mitelman Database of Chromosome Aberrations in Cancer, 2005_12

47,210

MDR

Medical Dictionary for Regulatory Activities Terminology, 14.0

1,897

MEDLINEPLUS

MedlinePlus Health Topics, 20080614

900

MGED

MGED Ontology, 131

310,485

MSH

Medical Subject Headings, 2011_2010_08_30

85,138

MTH

UMLS Metathesaurus, 2010AB

19,880

MTHFDA

Metathesaurus FDA National Drug Code Directory, 2010_08_02

337

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2010

16,081

MTHICD9

International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2011

94

MTHICPC2ICD107B

ICPC2 - ICD10 Thesaurus, 7-bit Equivalents, 0412

76

MTHICPC2ICD10AE

ICPC2 - ICD10 Thesaurus, American English Equivalents, 0412

1,633

MTHMST

Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001

12,969

MTHSPL

Metathesaurus FDA Structured Product Labels, 2010_08_27

478,187

NCBI

NCBI Taxonomy, 2010_04_29

135

NCIMTH

NCI Metathesaurus

38,863

NDFRT

National Drug File, 2010_09_07

1,781

NPO

NPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2010_10_31

63,924

OMIM

Online Mendelian Inheritance in Man, 2010_04_08

9,869

PDQ

Physician Data Query, 2010_08_06

2,041

PMA

Portfolio Management Application, 2010

268

PNDS

Perioperative Nursing Data Set, 2nd edition, 2002

940

QMR

Quick Medical Reference (QMR), 1996

30,033

RADLEX

RadLex, 3_33

227,498

RXNORM

RxNorm Vocabulary, 10AA_100907F

281,843

SNOMEDCT

SNOMED Clinical Terms

4,808

SPN

Standard Product Nomenclature, 2003

156

SRC

Metathesaurus Source Terminology Names

13,788

UMD

UMDNS: product category thesaurus, 2010

1,765

USPMG

USP Model Guidelines, 2004

61,191

UWDA

University of Washington Digital Anatomist, 1.7.3

26,546

VANDF

Veterans Health Administration National Drug File, 2010_07_26

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