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From previous discussions, representatives of the U.S. National Cancer Institute, the United Kingdom clinical trial system, and the European Organisation for Research and Treatment of Cancer agreed to work together to develop an initiative to promote international clinical trials in rare cancers otherwise lacking infrastructural support. Each organization went to their specific disease-oriented groups, queried their interest and capabilities, and prioritized five "first tier" diseases for this initiative.  The group identified individuals to chair disease-specific meetings at the 2011 American Society of Clinical Oncology (ASCO) conference in Chicago, with the goal of bringing together world leaders in these diseases. The results of these meetings will be collected on this wiki.

The five initial disease areas for this effort include:

  1. Penile cancer
  2. Gynecological sarcoma
  3. Fibrolamellar hepatocellular carcinoma
  4. Rare head and neck tumors (anaplastic thyroid cancer and salivary cancers)
  5. Small bowel cancers
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