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A Non-Canonical Case is any case other than a canonical or canonical-plus case. A non-canonical case has analytes shipped, but either not from the appropriate sample types or not to all required characterization and sequencing centers. The data from the characterization of these samples may or may not have scientific value. Non-canonical cases generally do not count toward the overall management goals of cases characterized for the main TCGA project; however, the canonical status of a case should not be used for this accounting purpose as there too many exceptions.

Notes:

  • "Non-Canonical" status is not necessarily permanent. It is conceivable that additional samples could be added to an incomplete case, which would then meet the minimal requirements of TCGA; if analytes from such additional samples are distributed as necessary, the case would be promoted to "Canonical" or "Canonical-Plus," as appropriate

Examples:

  • 1 primary untreated tumor sample only. For example, TCGA GBM batch 5, which includes only tumor samples.
  • Cases from which the tumor or normal samples were derived ONLY from fixed-formalin paraffin-embedded (FFPE).
  • Cases with insufficient nucleic acids for all characterization on all standard TCGA platforms for which a subset of characterization was performed.
  • 1 normal sample only ("normal normals") used as tissue controls and obtained from an individual who did not have cancer.