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The caCORE caDSR 4.x Technical Guide describes the Cancer Data Standards Registry and Repository (caDSR) component of the Cancer Common Ontologic Representation Environment (caCORE). caCORE is an open-source, standards-based, semantics-computing environment and toolset created by the National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT). The caDSR is a metadata registry and repository, based on the ISO/IEC 11179 standard, and is used to register the descriptive information needed to render cancer research data reusable and interoperable. The caBIO, EVS and caDSR data classes are registered in the caDSR as are the data elements on NCI-sponsored clinical trials case report forms.