Input: 1. Thesaurus.owl (the inferred version)
       2. Value set definition xml files

Processing:
Step 1: Find all parent-child (subClassOf) and concept_in_subset (A8) relationships in NCI Thesaurus.


	parent-child (subClassOf):
		Potency Unit|C48470|Biscuit Dosing Unit|C111139
		Antiparasitic Agent|C276|Milbemycin A3 5-Oxime|C87654
		Application|C60755|Product Correspondence|C97024
		Country|C25464|Yemen|C17264
		Peptide Vaccine|C1752|HLA-A*0201-Restricted URLC10-VEGFR1-VEGFR2 Multipeptide Vaccine|C77900
		Pharmacologic Management|C21090|Pharmacotherapy Discontinuation|C128535
		Evaluator|C51824|Macroscopic Findings Evaluator|C119859
		CDISC Questionnaire Terminology|C100110|CDISC Questionnaire DLQI Test Name Terminology|C119069
		Malignant Osteoblast|C36901|Malignant Fusiform Osteoblast|C67521
		Receptor|C18106|Programmed Cell Death 1 Ligand 1|C96024
		WISP2 Gene|C21417|WISP2 wt Allele|C52966
	...
	...


	concept_in_subset:
		C61305|A8|C63923
		C61305|A8|C128784
		C2048|A8|C128784
		C123164|A8|C90259
		C123164|A8|C123272
		C123165|A8|C90259
		C123165|A8|C123272
		C120556|A8|C116978
		C120556|A8|C116977
		C120556|A8|C128784
		C2688|A8|C116978
		C2688|A8|C116977
		...
		...


Step 2: Parse value set definition xml files to get data required for resolving the corresponding value sets.

Step 3: Resolve all value sets based on the data found in Steps 1 and 2 above.
        This step will produce:
        - a set of concepts that belong to at least one value set
        - a one to many mapping from the above concept codes to the URIs of value sets to which they belong.
        

Resolve value sets: 
1|CDISC_Questionnaire_Terminology.txt|http://evs.nci.nih.gov/valueset/C100110|3346
2|CDISC_Questionnaire_Category_Terminology.txt|http://evs.nci.nih.gov/valueset/C100129|402
3|CDISC_SDTM_Relationship_to_Subject_Terminology.txt|http://evs.nci.nih.gov/valueset/C100130|58
4|CDISC_Questionnaire_ADAS-Cog_CDISC_Version_Test_Name_Terminology.txt|http://evs.nci.nih.gov/valueset/C100131|110
5|CDISC_Questionnaire_ADAS-Cog_CDISC_Version_Test_Code_Terminology.txt|http://evs.nci.nih.gov/valueset/C100132|110
6|CDISC_Questionnaire_BPRS-A_Test_Name_Terminology.txt|http://evs.nci.nih.gov/valueset/C100133|18
7|CDISC_Questionnaire_BPRS-A_Test_Code_Terminology.txt|http://evs.nci.nih.gov/valueset/C100134|18
8|CDISC_Questionnaire_EQ-5D-3L_Test_Name_Terminology.txt|http://evs.nci.nih.gov/valueset/C100135|6
9|CDISC_Questionnaire_EQ-5D-3L_Test_Code_Terminology.txt|http://evs.nci.nih.gov/valueset/C100136|6
...
...
735|Product_Characteristic_ICSR_Terminology.txt|http://evs.nci.nih.gov/valueset/C99174|4
736|Substance_Administration_ICSR_Terminology.txt|http://evs.nci.nih.gov/valueset/C99175|1
737|SPL_Miscellaneous_Identifier_Types_Terminology.txt|http://evs.nci.nih.gov/valueset/C99288|3
738|CDISC_SDTM_Laterality_Terminology.txt|http://evs.nci.nih.gov/valueset/NICHD/C99073|7
739|CDISC_SDTM_Directionality_Terminology.txt|http://evs.nci.nih.gov/valueset/NICHD/C99074|32
740|NCIt_Neoplasm_Tree.txt|http://ncit:Neoplasm|8479
741|NDFRT_Mechanism_of_Action.txt|http://ndfrt:MoA|1
742|NDFRT_Physiologic_Effects.txt|http://ndfrt:PE|1
743|NDFRT_Structural_Class.txt|http://ndfrt:SC|1


Concepts that belong to at least one value set
(1) C105289
(2) C71913
(3) C71914
(4) C71911
(5) C71912
(6) C71910
(7) C105293
(8) C105292
(9) C105295
(10) C105294
(11) C71908
(12) C18772
(13) C105297
(14) C71907
(15) C105296
...
...
(49288) C16950
(49289) C16953
(49290) C16952
(49291) C52188
(49292) C52187
(49293) C52185
(49294) C52186
(49295) C52183
(49296) C52184
(49297) C52181
(49298) C52182
(49299) C16955



Mapping from the above concept codes to the URIs of value sets:
C105289|http://evs.nci.nih.gov/valueset/C100110
C105289|http://evs.nci.nih.gov/valueset/C105139
C105289|http://evs.nci.nih.gov/valueset/C105140
C105289|http://evs.nci.nih.gov/valueset/C61410
C105289|http://evs.nci.nih.gov/valueset/C66830
C71913|http://evs.nci.nih.gov/valueset/C63923
C71914|http://evs.nci.nih.gov/valueset/C63923
C71911|http://evs.nci.nih.gov/valueset/C63923
C71912|http://evs.nci.nih.gov/valueset/C63923
C71910|http://evs.nci.nih.gov/valueset/C63923
C105293|http://evs.nci.nih.gov/valueset/C100110
C105293|http://evs.nci.nih.gov/valueset/C105139
C105293|http://evs.nci.nih.gov/valueset/C105140
...
...
C52183|http://evs.nci.nih.gov/valueset/C63923
C52184|http://evs.nci.nih.gov/valueset/C128784
C52184|http://evs.nci.nih.gov/valueset/C63923
C52181|http://evs.nci.nih.gov/valueset/C63923
C52182|http://evs.nci.nih.gov/valueset/C128784
C16955|http://evs.nci.nih.gov/valueset/C106478
C16955|http://evs.nci.nih.gov/valueset/C106479
C16955|http://evs.nci.nih.gov/valueset/C118466
C16955|http://evs.nci.nih.gov/valueset/C61410
C16955|http://evs.nci.nih.gov/valueset/C66830
C16955|http://evs.nci.nih.gov/valueset/C90259
...
...
      
        

Step 4: Construct a new owl file to include concepts belonging to the set of concepts found above.
        Remove all but presentational properties (owl:AnnotationProperty) from the content of the corresponding NCIt (or NDFRT) concept.
        Remove all relationships (rdfs:subClassOf, owl:ObjectProperty, and owl annonymous classes) including equivalent class, restrictions,
        and associations, etc)
        Add new properties where the property name could be Value Set (a new owl:AnnotationProperty needs to be defined) and the property
        value would be the URI of the value set.


Example: C16955 (P8: VALUE SET annotation property)

    <owl:Class rdf:about="#C16955">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parity</rdfs:label>
        <P325 rdf:parseType="Literal"
            ><ncicp:ComplexDefinition><ncicp:def-definition>A measurement of the total number of live-born offspring a female has delivered.</ncicp:def-definition><ncicp:def-source>CDISC</ncicp:def-source></ncicp:ComplexDefinition></P325>
        <P97 rdf:parseType="Literal"
            ><ncicp:ComplexDefinition><ncicp:def-definition>The number of pregnancies reaching 20 weeks and 0 days of gestation or beyond, regardless of the number of fetuses or outcomes.</ncicp:def-definition><ncicp:def-source>NCI</ncicp:def-source><ncicp:attr>NICHD</ncicp:attr></ncicp:ComplexDefinition></P97>
        <P325 rdf:parseType="Literal"
            ><ncicp:ComplexDefinition><ncicp:def-definition>The number of pregnancies reaching 20 weeks and 0 days of gestation or beyond, regardless of the number of fetuses or outcomes.</ncicp:def-definition><ncicp:def-source>NICHD</ncicp:def-source></ncicp:ComplexDefinition></P325>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>BRTHLVN</ncicp:term-name><ncicp:term-group>PT</ncicp:term-group><ncicp:term-source>CDISC</ncicp:term-source><ncicp:source-code>SDTM-RPTESTCD</ncicp:source-code></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Live Birth Count</ncicp:term-name><ncicp:term-group>SY</ncicp:term-group><ncicp:term-source>NCI</ncicp:term-source></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Number of Live Births</ncicp:term-name><ncicp:term-group>PT</ncicp:term-group><ncicp:term-source>CDISC</ncicp:term-source><ncicp:source-code>SDTM-RPTEST</ncicp:source-code></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Number of Live Births</ncicp:term-name><ncicp:term-group>SY</ncicp:term-group><ncicp:term-source>CDISC</ncicp:term-source></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Para</ncicp:term-name><ncicp:term-group>SY</ncicp:term-group><ncicp:term-source>NCI</ncicp:term-source></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Parity</ncicp:term-name><ncicp:term-group>PT</ncicp:term-group><ncicp:term-source>NCI</ncicp:term-source></ncicp:ComplexTerm></P90>
        <P90 rdf:parseType="Literal"
            ><ncicp:ComplexTerm><ncicp:term-name>Parity</ncicp:term-name><ncicp:term-group>PT</ncicp:term-group><ncicp:term-source>NICHD</ncicp:term-source></ncicp:ComplexTerm></P90>
        <P207 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C0030563</P207>
        <code rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C16955</code>
        <P322 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CDISC</P322>
        <P322 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NICHD</P322>
        <P106 rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
            >Organism Attribute</P106>
        <P371 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parity</P371>
        <P108 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parity</P108>
        <P366 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parity</P366>
        
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C106478"/></P8>
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C106479"/></P8>
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C118466"/></P8>
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C61410"/></P8>
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C66830"/></P8>
        <P8 rdf:resource="http://evs.nci.nih.gov/valueset/C90259"/></P8>
    </owl:Class>


Output: NCI_Thesaurus_Value_Set.owl generated above.

Usage:
This owl file, once loaded, can be used for:
  - Code search:  (CNS union?)
  - Name search:  (CNS union?) restrictToMatchingDesignations, restrictToMatchingProperties
  - Resolve value set: Search concepts with a property matching a given URI.

All functions can be achieved through the native LexEVSAPI.
Possible convenience method - restrictToMatchingProperties on multiple matching values.

Implementation Details:
    - concepts in NDFRT or other terminologies. (use the namespace prefix)
    - assignment of coding scheme name and version, and namespace at load time.