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SYNOPSIS:

Current technology permits genome-wide generation of multidimensional molecular data assessing copy number alterations, nucleotide substitutions, insertion/deletions, rearrangements, and epigenetic changes.  Furthermore, next generation sequencing technology provides complete gene and genome sequence.  The CBIIT CGR team has created approaches and tools to integrate, display, and interpret these diverse, system-wide data generated by the next generation sequencing.  The CGR team has provided tools, analytic capacity, and bioinformatics support to the specific groups in the Cancer Genomic Atlas project (TCGA) and TARGET projects as well as investigators within the NCI community.  More specifically, the CBIIT - CGR team leveraged its analytic pipelines to determine the quality of data submitted to the data coordinating centers and to computationally identify features for confirmation by other groups and validation in bench-based experiments.  The team performed the primary sequence analysis for the TARGET consortium.  

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