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Introduction

Imaging-based cancer research is in the beginning phase of an Integrative-biology revolution. It is now feasible to extract large sets of quantitative image features relevant to prognosis or treatment across three complementary research domains:  in vivo clinical imaging, pre-clinical imaging, and digital pathology. These high-dimensional image feature sets can be used to infer clinical phenotypes or correlate with gene–protein signatures. This type of analysis, however, requires large volumes of image data. In this project, we propose to develop and deploy software that supports a comprehensive and reusable exploration and fusion of imaging, clinical, and molecular data. Within these three research domains, only one, clinical imaging, has made some progress in terms of establishing a framework and standards for informatics solutions.  For pre-clinical imaging and digital pathology, there are no such standards that allow for the seamless viewing, integration, and analysis of disparate data sets to produce integrated views of the data, quantitative analysis, data integration, and research or clinical decision support systems.

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  • NCI should incorporate data sharing requirements into grants.
  • NCI could create and fund projects that can only be successful if standards are utilized / developed (i.e., “pose questions that can only be answered through increased standardization”).

 

Strategy

The overarching goal of this project is to establish an informatics infrastructure that demonstrates the benefit and feasibility of data interoperability across the three domains:  Genomics, Diagnostic Imaging, and Digital Pathology.  The intent is to identify and address the interoperability needs to support specific research objectives, with the goal of demonstrating the need to scale up.  The scope is limited to pilot data sets, and the intent is only to demonstrate the infrastructure.  Creation of more robust tools that leverage the interoperability and infrastructure created in this project would be supported through extramural support after the benefit of scaling up has been demonstrated. 

Three complementary projects were proposed and approved.

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CTIIP Project Management and Status Meeting Materials