Page History

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• User can query for all pre-cancerous biospecimens from caTissue instances like those at Washington University, Thomas Jefferson University, and Holden Comprehensive Cancer Center.
• User can identify the sample obtained for Glioblastoma multiforme (GBM) and the corresponding CT image information. This query can be performed by querying across caTissue and NBIA using caB2B.
• User can find out if a sample used in an expression profiling experiment is available for a SNP analysis experiment. This query can be performed by querying across caTissue and caArray using caB2B.
• User can search for a particular gene based on the Entrez Gene ID and its related information  e.g. messenger RNA and protein information from GeneConnect.

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The CTRP has an immediate need for NCI level Vocabulary Services for Diseases and Interventions (Agents, Devices, etc.) that would allow CTRP to leverage the existing terms in EVS for these key lists of values, rather than relying on the existing lists taken from the PDQ Terminology File. And avoid the need for CTRP to build curation applications for these lists.

Searching infrastructure enhancements

A caB2B user sends out a grid query for all microarray data associated with subjects with lung cancer at the following institutes: 1) Dana Farber; 2) Mayo; 3) NCI; 4) Wash U St Louis. On the B2B webpage, a status bar appears listing the four microarray services being queried. Next to each service name is a status bar saying that results have not returned yet. There is also a button asking the user if she would like to end the query against this service. After 30 seconds, the status bar changes for the Dana Farber service. Suddenly, it says "4 results have returned" and the Dana Faber "End Query" button disappears. 22 seconds later, the same thing happens for Mayo, and 15 more results are "returned". Still, no results show up, and the user is looking at a status page. 11 seconds later, WUSTL returns with 57 results, at which point, the researcher decides to press the "End Query" button next to NCI. Suddenly all 83 results are returned, along with a message stating that the NCI query was terminated at the user's request.

A caB2B user wants to query for breast cancer tissue samples. caB2B The application shows her a list of 7 caTissue services available. Next to each service is a number that says how many public <Specimens> (could be a different object) are available at this service. Four of these services have zero specimens, so the user elects NOT to search against these services and selects the other 3 as candidate services to query.

A caB2B user queries for images of intestine cancer across 3 different NBIA services (WUSTL, Stanford, and Emory). The query is a union of results, and does not require results to be joined. After 41 seconds, image data is returned from Emory. The caB2Bwebpage displays these results to the user, along with a status bar at the top of the page indicating that \[2\] services have yet to return data. 72 seconds later, WUSTL returns data, which is immediately added to the results display the researcher is currently looking through. 113 seconds later, Stanford returns its data, and the results are appended to the bottom of the end of the results page. A message appears on the top of the page stating that all services have returned.

A caB2B user is interested in seeing any microarrays performed against lung samples obtained from non-smokers with stage 3 lung cancer. She queries Mayo and OSU because both hospital systems have been running independent lung cancer trials. Realizing that Mayo and OSU are working independently, she puts a flag into her search criteria indicating that cross institute joins are not required. InvisibleThe toweb theapplication usercreates either caB2B or FQP creates two the necessary queries, one joining across OSU and one joining across Mayo. For the Mayo join, data returns from caTissue after 32 seconds, and 43 seconds later, followed by data from the Mayo caArray returnsservice. The FQPapplication recognizes joinsthat these two datasets can be joined together based on the specimen ID and returns results to caB2B after 75 secondsthe user. These results are displayed to the user along with a message stating that \[1\] institute has not returned data to date. 1:13 A minute or two later, the data from the missing OSUinstitute returns and is appended to the results from Mayo that the user is currently browsing through.