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image representing ISA-TAB-Nano Extension - Study, Investigation, Assay, Material

Info
titleISA-TAB Specification

ISA-TAB-Nano extends ISA-TAB, an existing specification developed by the ISA-commmunity.  Please refer to the ISA-TAB Specification

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for guidelines on the format of ISA-TAB.

Click here for ISA-TAB-Nano OVERVIEW PRESENTATION - a great place to start!

ISA-TAB-Nano Paper:

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BMC Biotechnology 2013, 13:2 Published: 14 January 2013

Commentary

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Nature Nanotechnology 2013, 8, 73-74 Published: 5 February 2013

Blog ISA-TAB-Nano Code Fest: Community building and coding to advance nanotechnology data exchange, Bethesda, Maryland, May 9-10, 2013

ISA-TAB-Nano: Click for each File type template: Investigation | Study | Material | Assay

See each File pages for more information and links to examples and glossaries.

Scope

This standard (ISA-TAB-Nano) specifies the format for representing and sharing information about nanomaterials, small molecules and biological specimens along with their assay characterization data (including metadata, and summary data) using spreadsheet or TAB-delimited files.

Prerequisites

Familiarity with the fields of nanotechnology and nanomedicine is a prerequisite for this specification. An understanding of ISA-TAB is recommended but not required as the ISA-TAB-Nano specification provides descriptive information on ISA-TAB as applied to nanotechnology.

Version

The current version of ISA-TAB-Nano is Version 1.2 (March 2014). Differences between Version 1.2 and 1.1 are described in the ISA-TAB-Nano 1.2 Release Notes. Differences between Version 1.1 and 1.0 are described in the ISA-TAB-Nano Code Fest De-Brief presentation and in the ISA-TAB-Nano 1.1 Release Notes.

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Investigation Title: Nanotechnology Characterization Laboratory (NCL) Dendrimer-Based MRI Contrast Agent

Investigation Description: The objective of this investigation is to characterize a PAMAM dendrimer with an associated gadolinium chelate MRI contrast agent. The nanomaterials submitted for testing at the NCL were (NCL20) G4 tris (hydroxyl) terminated PAMAM dendrimer, (NCL21) G4 pyrrolidinone terminated PAMAM dendrimer, (NCL22) G4.5 COONa terminated PAMAM dendrimer, (NCL23) G4.5 COONa terminated PAMAM dendrimer-Magnevist® complex, (NCL25) G4 tris (hydroxyl) terminated PAMAM dendrimer-Magnevist® complex, and (NCL26) G4 pyrrolidinone terminated PAMAM dendrimer-Magnevist® complex. Commercially available Magnevist® (NCL24) was used as a control. NCL studies addressed in this report can be divided into three main categories: physicochemical characterization; immunotoxicology; in vitro toxicology.

Example Files

ISA-TAB-Nano Curated Examples