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Page History
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| A | B |
|---|---|
| Investigation Identifier | NCL200612A |
| Investigation Title | Dendrimer-Based MRI Contrast Agents |
| Investigation Description | The goal of this investigation is to characterize a PAMAM dendrimer with an associated gadolinium chelate MRI contrast agent. |
| Investigation Submission Date | 2002-11-30 |
| Investigation Public Release Date | 2002-11-30 |
| Investigation Disease | |
| Investigation Disease Term Accession Number | |
| Investigation Disease Term Source REF | |
| Investigation Outcome |
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| A | B |
|---|---|
| Study Identifier | NCL200612A-CytoxicityLLC-PK1 |
| Study Title | Cytotoxicity characterization in LLC-PK1 cells |
| Study Description | Nanoparticle biocompatibility was evaluated in the porcine renal proximal tubule cell line, LLC-PK1. Cytotoxicity was determined as described in the NCL protocol for LLC-PK1 Kidney Cytotoxicity Assay(GTA-1). Briefly, test materials were diluted to the desired assay concentrations in cell culture media. Cells were preincubated for 24 h prior to adding test material, reaching an approximate confluence of 80%. Cells were exposed to test material for 6, 24 and 48 h, and cytotoxicity was determined using the MTT cell viability and LDH membrane integrity assays. |
| Study Submission Date | 2002-11-30 |
| Study Public Release Date | 2002-11-30 |
| Study Disease | |
| Study Disease Term Accession Number | |
| Study Disease Term Source REF | |
| Study Outcome | NCL22, NCL23 and NCL24 were found to be minimally cytotoxic, under the testing conditions utilized. |
| Study File Name | s_cytotoxicity-LLC-PK1.xls |
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