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caDSR Wiki | caDSR Database and Tools | caDSR Documentation
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The NCI caDSR CDE Browser can be used to download collections of metadata describing data held in repositories for cancer research and clinical trials. There are currently no NCI Recommended CDEs for use other than the  CDEs marked as having a Registration Status of "Standard".  Any CDE in caDSR can be reused, but the ones marked "Standard" have been through a broader governance process. There communities within NCI who have agreed to use a set of CDEs for specific purposes, for example EDRN, TCGA, NCTN, and many others.  If you wish to collect data that is compatible with a specific group, you should begin by looking for the group's CDEs using the CDE Browser.  The Context name is an organizing principle for tree based navigation, and the "Advanced Search" provides a way to search for CDEs grouped by Classifications, or keywords.

Best Practices for creating CDEs  can be found here.

The caDSR Form Builder can be used to create, view and download the Case Report Forms (CRFs) designs.

Currently, CDEs can be downloaded in Excel or XML Format, CRFs can be downloaded in Excel format.

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caDSR Production CDEs in XML 

 Form Builder Logo


   CDEs as Excel CDEs as XML CRF as Excel

          CDEs as Excel             CDEs as XML             CRF as Excel

Attempting to download all the caDSR CDEs would result in a file size that is too large for a single MS Excel download, and currently forms can only be downloaded one form at a time.

Therefore, "canned", or pre-downloaded collections of all the NCI Standard CDEs, and "Released" CDEs, and CDEs by selected individual projects in is provided for your convenience.

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Download NCI Standard CDEs

The NCI regularly reviews and harmonizes CDEs in use by the community. The NCI Standard CDEs represent those that have been through the NCI's Content Owners Governance and have been determined to meet all the necessary criteria for standardization based on NCI Best Practices. When looking for NCI recommended CDEs, this is the place to start.  This format is mostly for downloading, a Browser based view for comparing or viewing details of these is available by visiting the CDE Browser and performing an Advanced Search, selecting Registration Status = Standard.

More reusable CDEs can be found by searching using the CDE Browser if you do not find CDEs in the Standard set that meet your needs.  to For more information about Content development at NCI, see caDSR Content.

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Community Released Downloads
Community Released Downloads
Download caDSR Community Released CDEs

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REDCap CDE and CRF Transformation Utilities - REDx

  • These are XSLT files that transform caDSR CDEs and Forms in XML format to a REDCap Data Dictionary:
  • The transformation utility converts a single or multiple Form represented in XML to REDCap compatible csv format
    • for CDE XML, the file may contain multiple CDEs
    • for CRF XML, the file can contain one or more form per transform, please select the correct version of the utility below
  • REDxCDEv5

    • Transformation utility to convert caDSR CDE Browser 4.0.5 XML download format into REDCap Data Dictionary as of 2016/10/02
    • Version 5 - 2016-10-27: Change transform to pull Min/Max Value instead of Min/Max Length
    • Version 4 - 2016-10-02: Add CDE ID/Version as "Field Annotation". Export Valid Values in teh same format as exported for CRFs, ensuring that CDE values/choices will be consistent for the same CDE used across studies, whether as a CRFs, or imported as a list of CDEs.
    • Version 3 - 2015-08-05: Change field note to contain the CDE Question Text, the field does not need to be lower-case without spaces, that rule applies only to variable name
    • Version 2.1 - 2015-6-18: Add instruction for customizing Form name, Id and Version
    • Version 2.0 - 2015-6-10: Add a check for existing CDE PV Values. If already a numeric, use existing value. If not, generate a unique value based on the position in the value list.
  • REDxCRFV10

Current NCI Standard CRFs

The NCI develops and publishes standard CRF templates for use in creating new clinical trials protocol forms.  Each CRFs consists of CDEs organized into 3 sections: mandatory, optional, and conditional CDEs. To retrieve these and any other forms registered in caDSR since the dates listed below, please visit the caDSR Form Builder, where a Guest account and password are provided for your convenience.

There are currently over 70 Standard CRFs released for production use. 

There are 60 CRFs that have been converted to REDCap format and can be found in the Shared Library, and in the zip file attached here.

NCI Standard CRFs: REDCap format Zip

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CDEs Initiatives

CDEs initiatives are owned by individual NCI Divisions, Offices, and Centers, as well as by NCI stakeholder communities who have chosen to use NCI caDSR as a central repository for their CDEs. The CDEs are organized in the caDSR CDE Browser based on Context and Classification Scheme.  Contexts represent a community who have agreed to share CDEs and CRFs, within a Context end users create Classification Schemes within caDSR for various projects in their community, and use them to classify and organize CDEs. The classifications are a list of keywords and categories familiar to the community. Opening up a Context in the CDE Browser will reveal a "Classifications" node, that when opened will list all the projects in alphabetical order. Clicking on a project node will return a list of all the CDEs for that project.

For prior downloaded versions of these collections, see the Attachments listed at the end of this page.  The date of the download is listed as the "as-of" date for each collection of CDEs.

If importing caDSR content from a download into another ISO/IEC 11179 or other similar CDE or CRF metadata registry, please add the caDSR Registration Authority Identifier (RAI) 2.16.840.1.113883.3.26.2 to the metadata to keep the caDSR content distinct from the local repository. Per ISO/IEC 11179, the RAI is part of a globally unique identifier known as the IRID (Item Registry Identifier), and uniquely identifies registry content as being related to particular registrars. The IRID for all caDSR content is the <caDSR OID + Item public Id + item version>. For example, if the caDSR item public id = 2181292, version = 1.1, when importing you would add the RAI, and the result would be an IRID = 2.16.840.1.113883.3.26.2 + 2181292 + 1.1.

 

 

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TCGA Phase II meta data elements (CDEs)

TCGA (The Cancer Genome Atlas) is a project funded by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI). A project overview can be found on the TCGA Home Page.

TCGA provides data element descriptions for the clinical data elements found in the TCGA data files.  The BCR on-line data dictionary displaying the essentials of the clinical CDEs as an HTML page is located here.  The files below contain all the caDSR metadata for these CDEs.  The HTML data dictionary was generated from the XML download of the TCGA CDEs. For more information or help creating your own HTML Data Dictionary from NCI registered CDEs, please contact the NCI Help Desk.

They are also available from the CDE Browser in the caBIG Context under the Classifications tab heading " TCGA 2.6 by Disease ".  New TCGA CDEs not yet in the BCR data dictionary can be found under the caBIG Classification "The Cancer Genome Atlas", sub-heading "New TCGA Data Elements"

Biomedical Research Integrated Domain Group (BRIDG) meta data elements (CDEs)

BRIDG is a model that was created by a collaborative effort engaging stakeholders from the Clinical Data Interchange Standards Consortium (CDISC), the HL7 BRIDG Work Group, the US National Cancer Institute (NCI), and the US Food and Drug Administration (FDA). A logical information model was developed to describe basic, pre-clinical, clinical, and translational research.  Please visit the BRIDG website for more information.

The CDEs in the BRIDG model are available from the CDE Browser in the BRIDG Context under the Classifications heading "Link to BRIDG 3.2", subheading "BRIDG 3.2". They have been downloaded and made available here for convenience.

 BRIDG 3.0.2 is also available in the Attachments section of this page and in the CDE Browser.

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North American Central Cancer Registries (NAACCR) meta data elements (CDEs)

NAACCR develops and promotes uniform data standards for cancer registration, and aggregates and publishes data from central cancer registries. It promotes the use of cancer surveillance data and systems for cancer control and epidemiological research. See their website for more information about NAACCR.

NCI has registered several versions of the NAACCR data elements as CDE metadata in caDSR for discovery and use by those wishing to utilize the NAACCR data, or create data repositories of compatible data.

The following versions of NAACCR have been recorded in caDSR, are available from the CDE Browser in the PS&CC Context under the Classifications tab heading "Division of Cancer Control and Population Sciences ". They have been downloaded and made available here for convenience.

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NAACCR Logo

National Biomedical Imaging Archive (NBIA)(formerly NCIA)

The CDEs in the HINTS 2005 survey are available from the CDE Browser in the caBIG Context under the Classifications heading "NBIA". They have been downloaded and made available here for convenience.

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Surveillance, Epidemiology and End Results (SEER) meta data elements (CDEs)

The SEER program works to provide information on cancer statistics in an effort to reduce the burden of cancer among the U.S. population.  The data elements collected in cancer surveillance have been registered in the NCI caDSR, and are available from the CDE Browser in the PS&CC Context under the Classifications tab heading "caSEER", subheading " com.imsweb.caseer ". They have been downloaded and made available here for convenience.

Health Information National Trends Survey (HINTS2005)

The CDEs in the HINTS 2005 survey are available from the CDE Browser in the PS&CC Context under the Classifications heading "HINTS2005". They have been downloaded and made available here for convenience.

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Electronic Medical Records and Genomics (eMerge) Network CDEs       

The CDEs in the eMerge project are available from the CDE Browser in the caBIG Context under the Classifications heading "eMerge Data Variables". They have been downloaded and made available here for convenience.

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Merge Network Logo

 

Attachments

caDSR Wiki | caDSR Database and Tools | caDSR Documentation

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