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How to Search for Markers in caDSR

1. Follow Steps 1 and 2 the initial steps in Adding Biomarkers, until the Markers page appears.
2. Next to the Name field, click caDSR
   . The Marker Search in caDSR window appears.
   

3. Enter all or part of the criteria for the search in the fields provided.

4. To restrict your search by case, next to Case-Sensitive Search, select Yes (the default is case-insensitive).

5. To highlight the term you searched for in the list of results, next to Highlight Query Text, select Yes.

6. Press the ENTER key on your keyboard, or click Search.

7. The results of your search are listed in a table with their permissible values

   Footnote
   The TSR document associated with a trial includes both the permissible value and alternates (synonyms).

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8. In the row that contains the appropriate marker, click Select.
   You are returned to the Add Marker page. The Marker Name field is populated with information from the marker you selected.

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How to Request Markers from HUGO for Addition to the caDSR Database

1. Follow Steps 1 and 2 the initial steps in Adding Biomarkers, until the Markers page appears.
2. Next to the Name field, click caDSR
   . The Marker Search in caDSR window appears.
   
3. Click Create Biomarker Request.
   The Create Permissible Value Request window appears, with your email address in the Sender's Email address field.
   
4. Select the Found in HUGO? check box, and then click the HUGO link.
   The window displays a new field for the HUGO marker code, and the HGNC database is launched in a new browser window.
5. Search for the marker in the HGNC database, and then enter the HGNC ID number for the appropriate record into the Hugo Marker Code field. This field is displayed only when you select the Found in HUGO? check box.
6. In the Text of marker as written in the protocol field, copy and paste, or enter, the information about the marker as it appears in the protocol.
7. Click Send Email.
   Your request is sent to the caDSR for processing. The value you requested is listed on the Pending Markers Report with the Pending status. You can return to the Pending Markers report later to enter the Public ID number once caDSR has sent notification to the Research Scientist that the new term was created. (See Processing New Biomarker Requests.)

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How to Edit Marker Records

1. Search for the trial of interest. In the search results, click the NCI Trial Identifier link for that trial.
2. On the Scientific Data menu, click Markers. The Follow the initial steps in Adding Biomarkers, until the Markers page appears.
   
3. To edit a marker, in the Edit column, click the Edit (pencil) icon.
   The Edit Marker page appears.

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4. Follow the instructions for selecting and saving attributes in Adding Biomarkers to change the recorded information.

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How to Delete Marker Records

1. Follow the initial steps in Adding Biomarkers, until the Markers page appears.
2. Do one of the following to select the markers you want to delete:
   
   1. To delete a marker(s), select the check box in the Delete column for the appropriate marker record(s). You can select multiple records.
      - or -
   2. To delete all markers, click Select All.
      The button changes to Deselect All.
3. Optionally, to clear all check boxes, click Deselect All.
4. Click Delete, and then confirm that you want to delete the record.

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How to Request New Permissible Values for Biomarkers

1. Follow Steps 1 and 2 the initial steps in Adding Biomarkers, until the Markers page appears.
2. Next to the Name field, click caDSR
   . The Marker Search in caDSR window appears.

3. Click Create Biomarker Request.

   The Create Permissible Value Request window appears, with your email address in the Sender's Email address field.

   
4. In the Marker Name field, enter the most appropriate biomarker name followed by the name as it appears in the protocol in parenthesis if the two are not identical.
5. In the Text of marker as written in the protocol field, copy and paste, or type, the information about the marker as it appears in the protocol.
   Click Send Email.
   Your request is sent to the caDSR for processing. The value you requested is listed on the Pending Markers Report with the Pending status. You can return to the trial later to accept it once it has been processed. (See Processing New Biomarker Requests.)

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