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The National Biomedical Imaging Archive (NBIAavailable both in the classic search interface and new search interface) is a free and open-source service and a software application that enables users to securely store, search, and download diagnostic medical images, providing a searchable national repository integrating in vivo cancer images with clinical data. Using role-based security, NBIA provides web-based access to de-identified DICOM images, image markup, annotations, and rich metadata. The NBIA download package is a ZIP package that includes the NBIA application, supporting libraries, the RSNA MIRC application (with NBIA modifications), documentation, and a sample NBIA database.