Precision Medicine Approach to Breast Cancer Detection and Diagnosis

• Dr. Yaffe will describe a multi-platform approach under investigation in his lab to improve the effectiveness of breast cancer detection and diagnosis. We are developing radiomic tools to guide the stratification of women for breast cancer screening that will be more accurate and efficient in detection than the “one size fits all” use of mammography whose accuracy suffers, particularly in dense breasts.  We employ microsimulation modeling to guide that work. We are also exploring the integration of radiomic information from in vivo medical images with histopathology, single-cell multiplex biomarker analysis, and targeted molecular sequencing to better characterize breast and other cancers and their immune environment and to explore their spatial heterogeneity.