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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117125,000 out of the 154178,946 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (2124.08e03D: May 2021March 2024)

Image RemovedImage Added

NCIt concepts with tagged synonyms from each outside source (2124.08e03D: August 2021March 2024)

716552231936604262516510315808243299

NCIt Concepts

Source

3ACC
1182ACC/AHA
20172016

BRIDG

408CareLex
56CBDD
268

CCPS

28081CDISC
769799CDISC-GLOSS
21192413Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
427CTEP
28277CTRP
636DIPG/DMG
1072EDQM-HC
2628228460FDA
239GAIA
12304GDC
1477HemOnc
127HL7
106ICD-10
664608ICDC
216ICH
215INC
5660mCode
1281MedDRA
150MRCT-Ctr
23NAACCR
246NCCN
510NCPDP
6NDC
4784NICHD
826OORO
71ORCHESTRA
18631220PCDC
40PI-RADS
377SEER
662SeroNet
237UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (202105202402: May 2021February 2024)

713 202101D 202101D 202101D1026 202101D24499 202101D 202101D5055 202101D 2021_01D632 202101D 202101D 202101D 202101D, 2021_01D158661 202101D5077 202101D5158 202101D 202101D 202101D 202101D4781 2021_01D879 202101D 202101D 202101D 2021_01D1437, 2021_01D 202101D

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_12D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2023_12D
27BRIDGBiomedical Research Integrated Domain Group Model, 20212023_01D12D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 20212023_01D12D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 20212023_01D12D
1725419304caDSRCancer Data Standards Registry and Repository, 20212023_01D12D
407CARELEXContent Archive Resource Exchange Lexicon, 20212023_01D12D
4953CBDDChemical Biology and Drug Development Vocabulary, 2021_01D2023_12D
265CCPSChildhood Cancer Predisposition Study, 2023_12D
922923CDCU.S. Centers for Disease Control and Prevention, 20212023_01D12D
2332429019CDISCClinical Data Interchange Standards Consortium, 20212023_01D12D
770800CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 20212023_01D12D
2000

2425

CELLOSAURUSCellosaurus, 20212023_01D12D
36883680CPTACClinical Proteomic Tumor Analysis Consortium, 20212023_01D12D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 20212023_01D12D
775CTCAECommon Terminology Criteria for Adverse Events, 20212023_01D12D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 20212023_01D12D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 20212023_01D12D
276CTDCClinical Trial Data Commons, 20212023_01D12D
318372CTEPCancer Therapy Evaluation Program, 2004373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 20212023_01D12D
2367528023CTRPClinical Trials Reporting Program, 20212023_01D12D
903904DCPNCI Division of Cancer Prevention Program, 20212023_01D12D
114DICOMDigital Imaging Communications in Medicine, 2021_01D2023_12D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_12D
694DTPNCI Developmental Therapeutics Program, 2023_12D
1070EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_12D
27355FDAU.S. Food and Drug Administration, 2023_12D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_12D
6030GDCNCI Genomic Data Commons, 2023_12D
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_12D
1439HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2023_12D
106ICD-10International Classification of Diseases, 10th Edition, 2023_12D
693ICDCNCI Integrated Canine Data Commons, 2023_12D
215ICHInternational Conference on Harmonization, 2023_12D
215INCInternational Neonatal Consortium, 2023_12D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2023_12D
244KEGGKEGG Pathway Database, 2023_12D
5660mCodeMinimal Common Oncology Data Elements, 2023_12D
183778NCINational Cancer Institute Thesaurus, 2023_12D
5079NCI-GLOSSNCI Dictionary of Cancer Terms, 2023_12D
5860NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_12D
129NCI-HL7NCI Health Level 7, 2023_12D
509NCPDPNational Council for Prescription Drug Programs, 2023_12D
5NDCNational Drug Code, 2023_12D
4780NICHDNational Institute of Child Health and Human Development, 2023_12D
825OOROOperational Ontology for Radiation Oncology, 2023_12D
70ORCHESTRAORCHESTRA, 2023_12D
1832PCDCPediatric Cancer Data Commons, 2023_12D
39PI-RADSProstate Imaging Reporting and Data System, 2023_12D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2023_12D
310RENIRegistry Nomenclature Information System, 2023_12D
659SeroNetSerological Sciences Network Terminology, 2023_12D
236UBERONUBERON Ontology, 2023_12D
1546UCUMUnified Code for Units of Measure, 2023_12D
77WHOWorld Health Organization (WHO) Terminology, 2023_12D
25ZFINZebrafish Model Organism Database, 2023_12D

NCIm concepts

Source Label - Other

Source Name

15881
15884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13256
13257CBOClinical Bioinformatics Ontology, 2011_02
280
544
CCS
CCSR_
10
ICD10CMClinical Classifications Software Refined for ICD-10-
PCS
CM,
2020
2023
537
357CCSR_
10
ICD10PCSClinical Classifications Software Refined for ICD-10
-CM, 20203079
-PCS, 2023
962CDCRECRace & Ethnicity - CDC, 1.2
3080COSTARCOSTAR, 1989-1995
16495
16485CSPCRISP Thesaurus, 2006
3844
3839CSTCOSTART, 1995
484
318CTEPCancer Therapy Evaluation Program, 2004
618CVXVaccines Administered, 2017_02_08,
2020
2023_
07
08_
28
16
8739
11414DRUGBANKDrugBank, 5.0_
2016
2023_
06_22, 5.0_2020_07_307289
08_11
7290DXPDXplain, 1994
102564
102551FMAFoundational Model of Anatomy Ontology, 4_15
7498
7482GARDGenetic and Rare Diseases Information Center, 2015_04
70907
71881GOGene Ontology,
2020
2023_05_
02
10
7392
8081HCPCSHealthcare Common Procedure Coding System,
2020
2023
41990
43627HGNCHUGO Gene Nomenclature Committee,
2020
2023_
05
04
9745
9078HL7V3.0HL7 Vocabulary Version 3.0,
2019
2023_
12
02
16693
19235HPOHuman Phenotype Ontology,
2020
2023_
06
07_
08
21
17424
17416ICD10ICD10, 2016
103155
105376ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2021
2024
190672
191545ICD10PCSICD-10-PCS,
2021
2024
20940
20886ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2874
2864ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
161239
175623LNCLOINC,
268
276
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
57970
62093MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA),
23
26_1
3375
3523MED-RTMedication Reference Terminology,
2020
2023_09_
08
05
2125
2123MEDLINEPLUSMedlinePlus Health Topics,
20191029
20221101
900MGEDMGED Ontology, 131
399713
456461MSHMedical Subject Headings,
2021
2024_
2020
2023_
07
08_
16
03
206928
218961MTHUMLS Metathesaurus,
2020AB
2023AB
8
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_
2014
2020
19016
19007MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
65727
57391MTHSPLMetathesaurus FDA Structured Product Labels,
2020
2023_08_
28
24
78
88MVXManufacturers of Vaccines,
2020
2023_09_
04
06
1907788
719490NCBINCBI Taxonomy,
2020
2023_
05
04_
21
13
7102
9532NCIMTHNCIMTH
0
NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
93898
103963OMIMOnline Mendelian Inheritance in Man,
2020
2023_
07
08_
27
10
12400
12399PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
260
270PNDSPerioperative Nursing Data Set,
4_2018
2021
940QMRQuick Medical Reference (QMR), 1996
45724
45826RADLEXRadLex, 4_
0
1
195824
217864RXNORMRxNorm Vocabulary, 20AA_
200908F
230905F
352065
361058SNOMEDCT_USUS Edition of SNOMED CT,
2020
2023_09_01
169
167SOPSource of Payment Typology, 9.2
4810
4811SPNStandard Product Nomenclature, 2003
210
230SRCMetathesaurus Source Terminology Names
28128
29104UMDUMDNS: product category thesaurus,
2020
2023
4808
5002USPUSP Compendial Nomenclature,
2020
2023_
02
08_
06
17
1605USPMGUSP Medicare Model Guidelines, 2020
61111
61107UWDAUniversity of Washington Digital Anatomist, 1.7.3
35546
38334VANDFVeterans Health Administration National Drug File,
2020
2023_
08
07_
03
31

Overall Counts (May 2021February 2024)

ConceptsRelationships Attributes Total Number of Terms
32,795684,128035

2423,431500,718918

 27 24,255395,262137 8 7,300098,055885