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  •  Matthew & Warren to write an email request to Toby pertaining to formalization of a business plan for ICDC
  •  Kuffel, Gina (NIH/NCI) [C] to work with Phil add description for NCATS DPI (supported clinical sequencing)

Agenda

Discussion ItemWhoNotes
Study Queue

Musk, Philip (NIH/NCI) 

  • COTC021: Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma
    • This is the parallel arm to COTC022: SOC in dogs with Osteosarcoma that was previously uploaded to the ICDC
    • Clinical data for 152 dogs. mRNAseq for 93 dogs
    • Imaging, genomics, proteomics, immunology, clinical
    • Presented to DGAB, recommendation for the Senior Advisory Committee is in progress 
  • UBC03
    • Approved by SAC on 8/13/22
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • Purdue University
    • 19 cases
    • Status: 2nd round of templates sent by submitter, next call is set to review v2 files
  • OSA02
    • Approved by SAC on 9/22/22
    • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma"
    • Colorado State University
    • 108 cases
    • Status: Submitters generating template-based loading files, reviewing hospital records to extract staging information and progression/survival data
  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Loaded into the Dev environment and indexing to be submitted to DCF this week, data subject to embargo
  • UC01
    • Approved by SAC on 12/22/22
    • "Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation"
    • North Carolina State University
    • 36 cases, 73 files (1.5 TB)
    • Status: Released to production on 4/13/23
  • PRECINCT01 
    • Approved by SAC on 6/28/22
    • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases"
    • UC Davis
    • 21 cases
    • Status: Most data not yet available, pathology reports have been fully redacted and adverse event metadata coming soon, some files have been transferred, bucket permissions resolved, cytokine data is now available
  • PRECINCT02
    • Approved by SAC on 12/8/22
    • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
    • Tufts University
47
    • 49 cases
    • Status: Submitter has generated version 2 of template-based data loading files
  • PANCAN01
    • Approved by SAC on 11/8/21
    • "Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds"
    • University of Georgia
    • 684 cases
    • Status: Submitters generating template-based loading files, data manager PoC has been identified, candidate study has been identified to move forward
  • OSA03
    • Approved by SAC on 4/19/21
    • "Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma"
    • University of Minnesota
    • 44 cases
    • Status: Released to production on May 24, 2023 

Minutes (Not Verbatim)

Gina presented data submission request COTC021

WK - moved this to a vote

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