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This section outlines the EVS terminology content and tools whose use is described in the subsequent sections of the EVS Use and Collaborations document. The following resources are described.

Associated downloads are being made available on the EVS Downloads web page.

Controlled Terminology

EVS produces two major reference resources, NCI Thesaurus and NCI Metathesaurus, in collaboration with a range of partners. EVS also produces, licenses, processes and makes available a wide range of other terminology content.

NCI Thesaurus (NCIt)

NCIt is NCI's reference terminology and core biomedical ontology. It covers some 120,000 key biomedical concepts with a rich set of terms, codes, 115,000 textual definitions, and over 400,000 inter-concept relationships, and is used to code most NCI metadata and models. More than 500 concepts are added each month, and many more existing concepts are updated, in response to user requests and the requirements of dependent systems and applications. Many of these concepts include content created and maintained jointly with NCI's partners, making NCIt a shared coding and semantic infrastructure resource (see Shared Terminology Development section).

NCI Metathesaurus (NCIm)

NCIm currently consists of more than 85 biomedical terminologies whose 6,700,000 terms are mapped to 2,800,000 concepts representing their shared meanings; there are more than 31,000,000 cross-links between content elements. NCIm is updated approximately six times a year, growing by some 100,000 concepts annually. This growth involves adding new terminologies, and updated versions of existing terminologies, to meet the requirements of EVS users for specific terminologies and for mappings between them. NCIm also provides a rich reference resource for a broad range of users seeking definitions, synonyms, codes, and other information.

Other Terminologies

EVS licenses, processes and makes available many other terminologies through standardized application and browser interfaces, and frequently through various data file formats as well. EVS has helped create, harmonize with, and publish several of these terminologies. Currently available are:

• ChEBI: Chemical Entities of Biological Interest
• CTCAE: Common Terminology Criteria for Adverse Events
• GO: Gene Ontology
• HGNC: Human Genome Organisation (HUGO) Gene Nomenclature Committee
• HL7: Health Level 7 RIM V3
• ICD-9-CM: International Classification of Diseases, Ninth Revision, Clinical Modification
• ICD-10: International Classification of Diseases, Tenth Revision
• ICD-10-CM: International Classification of Diseases, Tenth Revision, Clinical Modification
• LOINC: Logical Observation Identifiers Names and Codes
• MA: Adult Mouse Anatomy
• MedDRA: Medical Dictionary for Regulatory Activities Terminology
• MGED Ontology: Microarray Gene Expression Data Ontology
• MED-RT: Medication Reference Terminology
• NPO: NanoParticle Ontology
• OBI: Ontology for Biomedical Investigations
• PDQ: Physician Data Query
• RadLex: Radiology Lexicon
• SNOMED CT: Systematized Nomenclature of Medicine-Clinical Terms
• UMLS SemNet: UMLS Semantic Network
• Zebrafish: Zebrafish Model Organism Database

Terminology Value Sets

Value sets provide a standardized representation of selected values from these terminologies, covering a range of standards from CDISC, FDA, NCPDP, NDF-RT, NICHD, and others.

Terminology Mappings

Mappings between several supported terminologies have also been published:

• GO to NCIt Mapping
• Mouse Anatomy (MA) to NCIt Mapping
• NCIt to ChEBI Mapping
• NCIt to HGNC Mapping
• NCIt to SwissProt Mapping
• PDQ to NCIt Mapping
• ICD-O-3 to NCIt Mapping