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  • NCI Thesaurus (NCIt) is NCI's reference terminology and core biomedical ontology, covering  key biomedical concepts with a rich set of terms, codes, textual definitions, and inter-concept relationships. NCIt combined and extended core NCI terminologies within a scientifically and technically rigorous framework. NCIt is now a broadly shared coding and semantic infrastructure resource – over half of NCIt concepts include content explicitly tagged by one or more EVS partners (for additional information including detailed statistics see the shared terminology development wiki page ).
  • NCI Metathesaurus (NCIm)  provides a broad, concept-based representation of terms from over 110 biomedical terminologies, representing their shared meanings. NCIm contains most terminologies used by NCI for clinical care, translational and basic research, and provides a rich source of definitions, synonyms, codes, and other information. NCIm starts from a subset of NLM's UMLS Metathesaurus, and modifies and extends it with many additional sources.
  • Other Terminologies : EVS licenses, processes and makes available individually through EVS systems, many other terminologies of special interest to NCI and the research community. EVS has helped create, harmonize with, and publish several of these terminologies.  NCI EVS Explore hosts terminologies an integrated environment, providing search, cross-links, and a user friendly interface to ICD-10-CM, CTCAE, MedDRA, SNOMED CT, MED-RT, GO, and many other terminologies and ontologies used by NCI and its partners.
  • Terminology Mappings: Pairwise mappings between several supported terminologies have also been created and published to support data translation and cross-reference. As with standalone terminologies above, such mappings generally reflect special EVS community interests and collaborations.
  • Terminology Subsets, Value Sets and Data Standards: EVS works with many partners to create and support standardized terminology for biomedical coding.  Hundreds of NCIt subsets and other code lists are maintained by EVS, and most are now available as CTS 2 value sets following the draft Common Terminology Services Release 2 (CTS 2) specification . In caDSR, they provide a pre-curated standard set of meanings for use by metadata curators.  More than 1300 value sets are currently defined in EVS, most as subsets of NCIt covering a range of standards from many EVS partners.  Key  Key EVS supported terminology standards include:

    • FDA Terminology : EVS is working with the U.S. Food and Drug Administration (FDA) to develop and support controlled terminology in several areas. More than 25,000 FDA terms and codes are stored in NCIt.

    • CDISC Terminology : The Clinical Data Interchange Standards Consortium (CDISC) -- an international, non-profit organization that develops and supports global data standards for medical research -- has chosen EVS as its terminology partner.

    • NCPDP Terminology : The National Council for Prescription Drug Programs (NCPDP) creates and promotes the transfer of data related to medications, supplies, and services through the development of standards and industry guidance, and now uses NCIt in two of its standards.

    • Pediatric Terminology : The National Institute of Child Health and Human Development (NICHD) and EVS are working with numerous contributors from national and international academic, clinical and research institutions to provide standardized terminology for coding pediatric clinical trials and other research activities.

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