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h1. {page-info:title}
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Semantic Infrastructure Domain User Story 6:
Discover and orchestrate services to achieve LS research goals; e.g.
...
start
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with
...
a
...
hypothesis,
...
identify
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relevant
...
services
...
that
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provides
...
the
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necessary
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analysis
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and
...
data,
...
create
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the
...
worklow/pipeline,
...
report
...
findings.
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Domain
...
Description
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Revised
...
From
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ICRi
...
Use
...
Cases
...
A
...
scientist
...
is
...
trying
...
to
...
identify
...
a
...
new
...
genetic
...
biomarker
...
for
...
HER2/neu
...
negative
...
stage
...
I
...
breast
...
cancer
...
patients.
...
The
...
scientist
...
queries
...
for
...
HER2/neu
...
negative
...
tissue
...
specimens
...
of
...
Stage
...
I
...
breast
...
cancer
...
patients
...
using
...
services
...
at
...
his/her
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cancer
...
center
...
that
...
also
...
have
...
corresponding
...
microarray
...
experiments.
...
Analysis
...
of
...
the
...
microarray
...
experiments
...
identify
...
genes
...
that
...
are
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significantly
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over-expressed
...
and
...
under-expressed
...
in
...
a
...
number
...
of
...
cases.
...
The
...
scientist
...
decides
...
that
...
these
...
results
...
are
...
significant,
...
and
...
related
...
literature
...
suggest
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a
...
hypothesis
...
that
...
gene
...
A
...
may
...
serve
...
as
...
a
...
biomarker
...
in
...
HER2/neu
...
negative
...
Stage
...
I
...
breast
...
cancer.
...
To
...
validate
...
this
...
hypothesis
...
in
...
a
...
significant
...
number
...
of
...
cases
...
the
...
scientist
...
needs
...
a
...
larger
...
data
...
set,
...
so
...
he
...
queries
...
for
...
all
...
the
...
HER2/neu
...
negative
...
specimens
...
of
...
Stage
...
I
...
breast
...
cancer
...
patients
...
with
...
corresponding
...
microarray
...
data
...
and
...
also
...
for
...
appropriate
...
control
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data
...
from
...
other
...
cancer
...
centers.
...
After
...
retrieving
...
the
...
microarray
...
experiments
...
the
...
scientist
...
analyzes
...
the
...
data
...
for
...
over-expression
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of
...
genes
...
A.
...
Technical
...
Description
...
The
...
scientist
...
in
...
this
...
case
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is
...
trying
...
to
...
develop
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a
...
workflow
...
that
...
will
...
assist
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biomarker
...
discovery
...
research.
...
S/he
...
first
...
needs
...
to
...
discover
...
the
...
services
...
that
...
provide
...
biospecimen
...
information
...
with
...
the
...
phenotype
...
s/he
...
is
...
looking
...
for
...
(e.g.
...
HER2/neu
...
negative
...
stage
...
I
...
breast
...
cancer)
...
and
...
then
...
the
...
microarray
...
experiment
...
information.
...
Then
...
he
...
needs
...
to
...
create
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a
...
workflow
...
(orchestrate
...
services)
...
where
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the
...
input
...
is
...
a
...
phenotype
...
for
...
biospecimens
...
and
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output
...
is
...
a
...
set
...
of
...
gene
...
of
...
interest.
...
These
...
steps
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require
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the
...
support
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for
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standard
...
terminologies
...
(and
...
services)
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and
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syntaxes
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to
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best
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describe
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the
...
services'
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behavior
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and
...
static
...
data.
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Furthermore
...
they
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require
...
inference
...
engines
...
that
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relates
...
the
...
semantic
...
and
...
syntactic
...
metadata
...
for
...
the
...
inputs/outputs
...
of
...
the
...
services
...
to
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"assist"
...
scientist
...
to
...
identify
...
what
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service
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can
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be
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part
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of
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the
...
workflow.
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Cross
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Reference
...
Support
...
development
...
of
...
workflows:
...
...
Request
Requirements Input
Requirements Input
ICR ICRi Use Cases
Related Services
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