NIH | National Cancer Institute | NCI Wiki  

WIKI MAINTENANCE NOTICE

Please be advised that NCI Wiki will be undergoing maintenance Monday, July 22nd between 1700 ET and 1800 ET and will be unavailable during this period.
Please ensure all work is saved before said time.

If you have any questions or concerns, please contact the CBIIT Atlassian Management Team.

Error rendering macro 'rw-search'

null

Versions Compared

Old Version 3

changes.mady.by.user Unknown User (wileyal)

Saved on

compared with

New Version 4

changes.mady.by.user Unknown User (wileyal)

Saved on

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.

...

Semantic Infrastructure Domain User Story 6:
Discover and orchestrate services to achieve LS research goals; e.g. start with a hypothesis, identify relevant services that provides the necessary analysis and data, create the worklow/pipeline, report findings.

Domain Description Revised From ICRi Use Cases

A scientist is trying to identify a new genetic biomarker for HER2/neu negative stage I breast cancer patients. The scientist queries for HER2/neu negative tissue specimens of Stage I breast cancer patients using services at his/her cancer center that also have corresponding microarray experiments. Analysis of the microarray experiments identify genes that are significantly over-expressed and under-expressed in a number of cases. The scientist decides that these results are significant, and related literature suggest a hypothesis that gene A may serve as a biomarker in HER2/neu negative Stage I breast cancer. To validate this hypothesis in a significant number of cases the scientist needs a larger data set, so he queries for all the HER2/neu negative specimens of Stage I breast cancer patients with corresponding microarray data and also for appropriate control data from other cancer centers. After retrieving the microarray experiments the scientist analyzes the data for over-expression of genes A.

...