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This page provides an example of the ISA-TAB-Nano Study file, leveraging data from The Study File will vary depending on whether the study performed is a physico-chemical characterization, in vitro characterization, or in vivo characterization.  Provided below are examples of Study Files for created from studies performed by the Nanotechnology Characterization Laboratory (NCL) Investigation (NCL200612A).

TABLE 1: Example Study File
 

Physico-Chemical Characterization Studies

Size Study

Size by Dynamic Light Scattering (DLS) Study

Dynamic Light Scattering (DLS) is a type of spectroscopy that uses a laser beam to irradiate a sample containing particles in suspension resulting in light scattering. Rapid fluctuations in scattering intensity around a mean value at a certain angle occur because of particle diffusion and are dependent upon on particle size. The calculated correlation function yields a diffusion coefficient, for a given temperature and viscosity, that can be used to calculate particle size.

StudyFileStudy Sample Study ParametersSupporting Information

Size_by_DLS

 

  • Nanoparticle Sample
  • pH
  • Concentration
 
Source   NameProtocol REFSample NamePerformerParameter   Value[pH]Parameter   Value[particle concentration]UnitTerm Accession   NumberTerm Source RefParameterValue[NaCl   concentration]UnitTerm Accession   NumberTerm Source RefMaterial TypeTerm Accession   NumberTerm Source RefMaterial FileProvider
NCL-20Measuring   the size of nanoparticles in aqueous media using batch-mode dynamic light   scatteringNCL-20-1Anil   Patri7.41mg/mLUO_0000176UO154mMUO_0000063UOnanoparticle   sampleNPO_1404NPOm_NCL-20.xlsDendritic   Nanotechnologies, Inc.
NCL-22Measuring   the size of nanoparticles in aqueous media using batch-mode dynamic light   scatteringNCL-22-1Anil   Patri7.41mg/mLUO_0000176UO154mMUO_0000063UOnanoparticle   sampleNPO_1404NPOm_NCL-22.xlsDendritic   Nanotechnologies, Inc.
NCL-23Measuring   the size of nanoparticles in aqueous media using batch-mode dynamic light   scatteringNCL-23-1Anil   Patri7.41mg/mLUO_0000176UO154mMUO_0000063UOnanoparticle   sampleNPO_1404NPOm_NCL-23.xlsDendritic   Nanotechnologies, Inc.