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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117,000 out of the 154,946 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (21.05a: May 2021)

NCIt concepts with tagged synonyms from each outside source (21.05a: May 2021)

NCIt Concepts

Source

3ACC
716ACC/AHA
2017

BRIDG

408CareLex
55CBDD
267

CCPS

21894CDISC
769CDISC-GLOSS
2067Cellosaurus
3661CPTAC
406CRCH
8924CTCAE
280CTDC
426CTEP
24562CTRP
1030EDQM-HC
26210FDA
239GAIA
5684GDC
127HL7
602ICDC
216ICH
215INC
1281MedDRA
23NAACCR
243NCCN
510NCPDP
6NDC
4784NICHD
1196PCDC
40PI-RADS
377SEER
298SeroNet
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908: August 2019)

NCIm concepts

Source Label - NCIt-derived

Source Name

713ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2021_01D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2021_01D
27BRIDGBiomedical Research Integrated Domain Group Model, 2021_01D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2021_01D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2021_01D
17254caDSRCancer Data Standards Registry and Repository, 2021_01D
407CARELEXContent Archive Resource Exchange Lexicon, 2021_01D
49CBDDChemical Biology and Drug Development Vocabulary, 2021_01D
923CDCU.S. Centers for Disease Control and Prevention, 2021_01D
23324CDISCClinical Data Interchange Standards Consortium, 2021_01D
770CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 2021_01D
2000CELLOSAURUSCellosaurus, 2021_01D
3688CPTACClinical Proteomic Tumor Analysis Consortium, 2021_01D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2021_01D
775CTCAECommon Terminology Criteria for Adverse Events, 2021_01D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2021_01D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 2021_01D
276CTDCClinical Trial Data Commons, 2021_01D
318CTEPCancer Therapy Evaluation Program, 2004
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2021_01D
23675CTRPClinical Trials Reporting Program, 2021_01D
903DCPNCI Division of Cancer Prevention Program, 2021_01D
114DICOMDigital Imaging Communications in Medicine, 2021_01D
694DTPNCI Developmental Therapeutics Program, 2021_01D
1026EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2021_01D
24499FDAU.S. Food and Drug Administration, 2021_01D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2021_01D
5055GDCNCI Genomic Data Commons, 2021_01D
281GENCGeopolitical Entities, Names, and Codes Standard, 2021_01D
632ICDCNCI Integrated Canine Data Commons, 2021_01D
215ICHInternational Conference on Harmonization, 2021_01D
215INCInternational Neonatal Consortium, 2021_01D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2021_01D
244KEGGKEGG Pathway Database, 2021_01D
158661NCINational Cancer Institute Thesaurus, 2021_01D
5077NCI-GLOSSNCI Dictionary of Cancer Terms, 2021_01D
5158NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2021_01D
129NCI-HL7NCI Health Level 7, 2021_01D
509NCPDPNational Council for Prescription Drug Programs, 2021_01D
5NDCNational Drug Code, 2021_01D
4781NICHDNational Institute of Child Health and Human Development, 2021_01D
879PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 2021_01D
1437UCUMUnified Code for Units of Measure, 2021_01D
25ZFINZebrafish Model Organism Database, 2021_01D
15,8734351029 NCBI   20180419106,313   2019020412,399   2,039     61,112

NCIm concepts

Source Label - Other

Source Name

15881AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 200313,255
13256CBOClinical Bioinformatics Ontology, 2011_02622
280CCS_10Clinical Classifications Software , 20053,080for ICD-10-PCS, 2020
537CCSR_10Clinical Classifications Software Refined for ICD-10-CM, 2020
3079COSTARCOSTAR, 1989-199516,501
16495CSPCRISP Thesaurus, 20063,843
3844CSTCOSTART, 1995
318

CTEP

Cancer Therapy Evaluation Program, 2004

484CVXVaccines   Administered, 20182017_1002_1808, 20192020_0307_04287,711
8739DRUGBANKDrugBank,   5.0_2016_06_22, 5.0_20192020_0107_31307,293
7289DXPDXplain, 1994102,404
102564FMAFoundational Model   of Anatomy Ontology, 4_10157,503
7498GARDGenetic and Rare   Diseases Information Center, 2015_0470,289
70907GOGene Ontology,   20182020_05_20026,655
7392HCPCSHealthcare Common   Procedure Coding System, 2019202041,301
41990HGNCHUGO Gene   Nomenclature Committee, 20182020_03059,789
9745HL7V3.0HL7 Vocabulary   Version 3.0, 20182019_081215,301
16693HPOHuman Phenotype   Ontology, 20182020_1106_08
17424ICD10ICD10, 2016
103155167ICD10CMInternational   Classification of Diseases, 10th Edition, Clinical Modification, 20192021
190,389190672ICD10PCSICD-10-PCS, 20192021
17,425ICD10ICD10, 2016
2094020,941ICD9CMInternational   Classification of Diseases, Ninth Revision, Clinical Modification, 20142,588
2874ICDOInternational   Classification of Disease for Oncology, 3_12
748ICPCInternational   Classification of Primary Care, 19935,057
5055ISO3166-2International   Organization for Standardization 3166-2, 2012146,331
161239LNCLOINC, 265268
41MCMMcMaster University   Epidemiology Terms, 1992
332MDBCACMitelman Database   of Chromosome Aberrations in Cancer, 2005_1256,014
57970MDRMedical Dictionary   for Regulatory Activities Terminology (MedDRA), 22.03,31523_1
3375MED-RTMedication   Reference Terminology, 20192020_0309_04082,119
2125MEDLINEPLUSMedlinePlus Health   Topics, 2018110820191029
900MGEDMGED Ontology, 131
373,575 399713 MSHMSHMedical Subject Headings, 20192021_20192020_01_0707_16
206928MTHUMLS Metathesaurus, 2020AB
8MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2014
521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19016
19,021
MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 20141,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
58,60065727MTHSPLMetathesaurus FDA Structured Product Labels, 20192020_0208_22
194,860

MTH

UMLS Metathesaurus, 2019AA

28
7876MVXManufacturers of Vaccines, 20182020_0809_31 1,409,50104
1907788NCBINCBI Taxonomy, 2020_05_21
 5,7497102NCIMTHNCIMTH
0 0NCISEERNCI SEER ICD   Neoplasm Code Mappings, 1999
0 NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05
0 NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_05
39,434 NDFRTNational Drug File,   2018_02_05
1887NPO1,887  NPONPO: NanoParticle   Ontology for Cancer Nanotechnology Research, 2011_12_08
93898OMIMOnline Mendelian Inheritance in Man, 2020_07_27
12400PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
260PNDSPerioperative Nursing Data Set, 4_2018
940QMRQuick Medical   Reference (QMR), 199645,733
45724RADLEXRadLex, 34_150201,450
195824RXNORMRxNorm Vocabulary,   18AB20AA_190304F200908F
347030352065SNOMEDCT_USUS Edition of   SNOMED CT, 20192020_0309_01162
169SOPSource of Payment   Typology, 894,810
4810SPNStandard Product   Nomenclature, 2003200
210SRCMetathesaurus   Source Terminology Names27,283
28128UMDUMDNS: product   category thesaurus, 2019
 1,693 USPMGUSP Medicare Model   Guidelines, 2017
 4,352 USPUSP Compendial   Nomenclature, 2018_12_10
2020
4808USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines, 2020
61111UWDAUniversity of   Washington Digital Anatomist, 1.7.334,194
35546VANDFVeterans Health   Administration National Drug File, 20192020_0208_0103

Overall Counts (August 2019)

ConceptsRelationships Attributes Total Number of Terms
3,265795,686128

2224,852431,144718

 25 27,184255,657262 7 8,508300,907055