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NCI Protégé is a collection of Protégé plug-ins developed for the NCI-specific editing environment. Protégé is an open-source development environment for ontologies and knowledge based systems. The OWL plug-in extends the environment to support the Web Ontology Language (OWL). Refer to the Protégé page for more information.

NCI Protégé is a collection of Protégé plug-ins used to edit the NCI Thesaurus. NCI Protégé provides a customized OWL editing environment, including additional editing and querying capabilities that are not available in the Protégé OWL plug-in. The NCI-specific plug-ins have been implemented as a tabbed interface. Beginning with NCI Protégé 1.3.0. this tool allows imports of ontologies in database mode and enables collaborators to begin "federating" ontologies.