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Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Musk, Philip (NIH/NCI) [C]

X
Warren KibbeX
Kim, Erika (NIH/NCI) [E]
X
Gregory TawaX
William Hendriks
X
Matthew Breen
X
Roel VerhaakX



Goals

  • Review, discuss, and prioritize ICDC study submission proposals

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Discussion ItemWhoNotes
Data submission request from Iowa State

Kuffel, Gina (NIH/NCI) [C] 

New data submission request from PRECINCT

Kuffel, Gina (NIH/NCI) [C] 

  • "Novel teatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
  • Data Submission Folder: DLBCL
Data submission approved by Senior Advisory Committee

Kuffel, Gina (NIH/NCI) [C] 

  • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
  • Data Submission Folder: OSA-Normal
  • Onboarding meeting set up with submitters
  • Study will be called OSA02
  • New program for Colorado State
PRECINCT Data Request Submission: Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases

All

Review of other Modiano publications: Other Modiano Publication Considerations.xlsx

Kuffel, Gina (NIH/NCI) [C]

Study Updates

Musk, Philip (NIH/NCI) [C]

  • TCL01
    • Still working on loading the data into our environments
  • PRECINCT01
    • Waiting on actual data files from UC Davis group
  • PANCAN01 (15 TB Re-analysis)
    • Submitter PoC identified 
  • OSA02
    • Dawn & Sunetra are working on the template-driven data submission

Minutes (Not Verbatim)

**Voting for Iowa State submission, only samples that have RNA-Seq data for Bladder Cancer and Healthy individuals**

In favor: Greg, Erika, Roel, Warren


**Questions answered from email sent to submitters on 10//22**

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  1. Will screening data be available in the future?
    • Depends on the contract, model is being developed by our lab, the model is owned by the lab
  2. Are there publications?
    • There is RNA-Seq data from a publication that is currently in review. This would be available nearly immediately.
  3. Will the organoids be made available to other researchers?
    • CRO approach, open to collaboration in the future.
  4. As a researcher interested in testing a particular compound...
    • There would be a MTA and we would test the compound using our organoids and share data back with the NIH.
  5. How do other labs reproduce research on the organoids?
    1. There is a paper coming out that gives exact specifications, collaborations are possible, but the organoids would stay at Iowa State. Open to colloabortions with industry and academia.