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Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
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Unknown User (leblancak)

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Otridge, John (NIH/NCI) [C]

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Kim, Erika (NIH/NCI) [E]

X

Sommers, Connie (NIH/NCI) [E]


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Debbie KnappX
Toby HechtX

Unknown User (parchmentr)


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Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

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  • Request for Information (RFI) has been issued
  • RFI has been promoted through the following channels
    • 2 focus groups met Ideas from the ICDC brainstorming sessions final.docx
    ItemWhoTalking Points
    DGAB Updates

    Kuffel, Gina (NIH/NCI) [C] 

    ICDC Studies in the Queue

    • UBC03
      • Approved by SAC on 8/13/22
      • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
      • Purdue University
      • 19 cases
      • Status: Submitters generating template-based data loading files
    • OSA02
      • Approved by SAC on 9/21/22
      • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma"
      • Colorado State University
      • 108 cases
      • Status: Submitters generating template-based data loading files
    • ORGANOIDS01
      • Approved by SAC on12/5/22
      • “Characterization of healthy and diseased canine tissues and organoids"
      • Iowa State University
      • Status: Submitters generating template-based data loading files
    • UBCO4
      • Approved by SAC on 12/22/22
      • "Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation"
      • North Carolina State University
      • 36 cases
      • Status: Onboarding kick-off call on 1/5/23
    • PRECINCT01 
      • Approved by SAC on 6/28/22
      • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases"
      • UC Davis
      • 21 cases
      • Status: Data not yet available
    • PRECINCT02
      • Approved by SAC on 12/8/22
      • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
      • Tufts University
      • 47 cases
      • Status: Data not yet available
    • PANCAN01
      • Approved by SAC on 11/8/21
      • "Canine tumor mutational burden is correleated with TP53 mutation across tumor types and breeds"
      • University of Georgia
      • 684 cases
      • Status: Submitters generating template-based data loading files
    • UMCVM
      • Approved by SAC on 4/19/21
      • "Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma"
      • University of Minnesota
      • 44 cases
      • Status: On hold until FTE is designated
    BPSC Updates

    Kuffel, Gina (NIH/NCI) [C] 

    • 2022 BPSC Review Article
      • Jeff Trent reached out relevant journal contacts
      • Feedback received will require us to emphasize the connection between dogs and humans and the value of canine as a comparative model
      • The paper has a genomic focus, however the comparative trials that exist are drug focused
      • Ideally we can site papers and studies that highlight relevant mechanisms with a genomic facet
      • No additional edits are allowed at this time
      • Authors are entering applicable PubMed central IDs
      • Cheryl London is completing references in EndNote
    Upcoming Steering Committee Meeting

    Unknown User (parchmentr)

    • Tuesday February 28, 2023
    • Proposed Agenda:

      Updates – Debbie

      Data Governance Advisory Board (DGAB) - Warren 

          • Genomic Data Guidelines – Elaine
          • Study Nominations/Data Submissions - Gina

      Best Practices Subcommittee (BPS) – Jeff 

          • White Paper/Publication – Jeff 
          • Genomics Working Group - Elaine, Debbie 
          • Imaging Working Group - Amy, Paula

      Presentations, New Collaborations, Opportunities - all

      Possible expansion of the Steering Committee

      Other Topics – all

      Administrative Topics – Ralph 

    		ICDC Next Phase Planning

    Unknown User (hechtt)

    ...

    Minutes (Not Verbatim)

    TH - Look at drug responses and the tumor itself to determine if there is a biomarker based on genomic expression. In the Intro of the BPSC paper, we could give examples of things that can be done based upon existing drug trial studies. 

    AL - In general, there is such a scarcity of credentialed biology in tumor progression. Drug mechanisms can be highlighted with an imaging reporter. 

    DK - Pre and post biopsies were attempted in Vemurafinib trial

    AL - Until we have DBs to refer to and a more stable reference genome it is difficult to make progress.


    Previous ICDC Use Cases from Steering Committee

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