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Page History
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| Committee Member | Present | Absent |
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| X | ||
| Amy Leblanc | X | |
| X | ||
| X | ||
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| Debbie Knapp | ||
| Toby Hecht | X | |
| Ralph Parchment | X |
Goals
- Discuss updates to ICDC and define emerging strategies and priorities
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- Debbie to work with Ralph to write invitation for Jaime Modiano
- Gina to speak with Debbie to arrange a meeting with Gerry to discuss data submission (Toby, Debbie, Phil)
- Revisit new steering committee members in September (loop Connie into this discussion)
Agenda
| Item | Who | Talking Points |
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Debbie Knapp
We asked FidoCure if they had data on glioma, osterosarcoma, bladder cancer, mucosal and acral melanoma, and mast cell tumor.
- Gerry Post replied “We do have data on osteosarcoma, mast cell tumors and some acral melanomas. As for gliomas and urothelial carcinomas, biopsies are much less common so we have less data.” Although he does not specify, I would think they would have lots of data on mucosal oral melanoma too.
- If we want to pursue this further, I think Gerry would like a more specific request that he will then take to his board.
| Discussion with FidoCure | Dr. Gerald Post, Chief Medical Officer at FidoCure Ben Toussant, Vice President of Operations at FidoCure |
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| New ICDC Subcommittee: Cross-Species Mapping Committee (CSMC) Purpose: Facilitation of human-canine comparative data analysis from the ICDC and other nodes in the CRDC using interoperability components such as Cancer Data Aggregator and aligning with data standards | All |
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New ICDC Subcommittee: Longitudinal Data Acquisition and Use Committee (LDAUC) Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC.. | All |
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| DGAB Updates | Recently Released ICDC Studies in Active Submission
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| New ICDC Bioinformatics Tutorial Website |
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| ICDC Biospecimen Data |
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| Upcoming Steering Committee Meeting | Ralph Parchment |
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Minutes (Not Verbatim)
TH - Golden Retriever Lifetime study has contacted us with biospecimen data, they would like a discussion. Could we have a page within the application to redirect users to biospecimen data? We could let them know about the potential for displaying URLs for their biospecimen data. We could organize this data by type (ie. plasma, mast cell, circulating tumor cells, etc.), we could provide contact information at the consortium level).
JO - This can serve as a maturation of what the ICDC can do.
RP - It is possible that some of the golden retrievers are still being monitored.
AL - Goldens are susceptible to all sorts of issues and diseases, it would be important to understand if they capture cancer specimens and diagnostic information.
EK - Sam is funded by the CCDI and is building data dictionaries for CCDI, confirming with the program that a collaboration would be supported.
JO - We are already working with Sam to implement platforms for CCDI.
TH - Gliomas can be studied in canine and pediatric data
AL - Osteosarcoma is another link
TH - In PRECINCT there was a trial in glioma that showed the significance between canine and pediatric data
JO - Another important resource to display within the ICDC could be relevant links to clinical trials from CCDI.
TH - We need to invite a rep from Pediatric Oncology to join the Steering Committee (could be a radiologist).
TH - We need to first figure out the plan of action for mapping canine/pediatric data and common data elements.
JO - Katherine Janeway from Dana Farber can be a potential
AL - Ronnie Roberts from Nationwide Children's hospital
TO - Adam Resnick from CHOP could be a potential collaborator, he focuses on gliomas.
Discussion with FidoCure
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Specific AI Question:
-Tumor, mutation, drug targets, inform outcomes correlation between
-Build dataset and R & D
-Improve outcomes for patients with diagnostics and therapy
-FidoCure is actually called OneHealth, dogs can be an unparalleled comparative model. We have the largest canine cancer dataset in the world, approaching 2 billion data points. Working on both sides of the leash. AL - There is a new veterinary journal coming under the umbrella of Nature, I will be a co-editor, titled Nature Veterinary Oncology, I wanted to ask for a submission about the ICDC, perhaps a perspectives piece.
Previous ICDC Use Cases from Steering Committee
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8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.
Action items
- Gina to speak with Debbie to arrange a meeting with Gerry to discuss data submission (Toby, Debbie, Phil)
- Toby to invite Greg from CCDI to the next Executive Team Meeting in January
- Toby to look across the NCI directory to find person that has a combination of canine and pediatric oncology background
