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The cost of DNA sequencing has dropped more than one-million-fold over the last decade, making it increasingly possible to discover the genetic basis of cancer and response to treatment. Three challenges impede this goal: 1) Analysts lack the resources to download, store and compute on the data; 2) Existing tools and infrastructure have not been designed to scale to handle petabytes or exabytes; and 3) Collaboration is hindered by the current model of storing data locally. The large-scale sequencing efforts of TCGA has begun to elucidate the genetic pathogenesis of cancer, enabling the development of targeted therapies. However, to enter an era of true “precision medicine,” we need to create sophisticated information technologies to store, analyze, and share data. FireCloud offers a solution to these needs. FireCloud democratizes data access and facilitates collaboration by providing a robust, scalable platform accessible to the community at large. Using the elastic compute capacity of Google Cloud, FireCloud empowers analysts, tool developers and production managers to perform large-scale analysis, engage in data curation, and store or publish results. FireCloud is modeled after Firehose, an analysis on-premesis infrastructure developed by the Getz Lab at the Broad |
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As in Firehose, workspaces are central to the FireCloud architecture. Workspaces are computational sandboxes that enable users to organize genomic data and metadata into a data model, run analysis methods, and view results. Users can upload their own analysis methods to workspaces or import the Broad institute’s best practice tools and pipelines. FireCloud will include tutorial workspaces, and carefully curated Open and Controlled Access TCGA workspaces which users can clone. FireCloud will enable the mission of TCGA and other cancer genome projects by provisioning workspaces with curated data and best practice tools and pipelines. This will empower researchers across the globe to explore the TCGA data in new and innovative ways which will increase opportunities to novel contributions to cancer research. |
Dr. Getz is an internationally acclaimed leader in cancer genome analysis and is pioneering widely used analytic programs in cancer genomic sequence analysis. Dr. Getz is an Associate Professor of Pathology in at Harvard Medical School. He is faculty and Director of Bioinformatics at the Massachusetts General Hospital Cancer Center and Department of Pathology, and is an Institute Member of the Broad Institute of Harvard and MIT, where he directs the Cancer Genome Computational Analysis Group. He is also the inaugural incumbent of the Paul C. Zamecnik Chair in Oncology at the MGH Cancer Center.
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You are invited to listen to Dr. Getz's presentation in Room 2W910-912 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast screencast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist
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About the NCI CBIIT Speaker Series:
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