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The Material File will vary depending on the type of nanomaterial described. The following sections provide examples of Material Files for common types of nanomaterials identified across nanotechnology resources.

Dendrimer

A dendrimer is a polymeric molecule which has a highly-branched, three-dimensional architecture. Dendrimers are synthesized from monomers and new branches are added in discrete steps to form a tree-like architecture. A high level of synthetic control is achieved through iterative reactions and purification at each step to regulate the size, architecture, functionality and monodispersity of the molecules. These polymers have desirable pharmacokinetic properties and a polyvalent array of surface groups that make them potential drug delivery vesicles.

Fullerene

A fullerene is one of the three known pure forms of carbon that exhibits a spherical shape with a hollow interior; named after Buckminster Fuller. The number of carbon atoms comprising fullerenes is variable; several stable spherical carbon structures containing 70 or more atoms have been documented.

Liposome

Liposomes are substances composed of layers of lipid that form hollow microscopic spheres within which drugs or agents could be contained for enhanced safety and efficacy. Based upon its size measured in nanometer range, a liposome can be categorized as a nanoparticle.

Carbon Nanotube

Carbon nanotubes (CNTs) are fullerene-like nanostructures that consist of graphene cylinders. The ends of the construct are closed with pentagonal-shaped rings.

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ISA-TAB-Nano examples leverage data from the Nanotechnology Characterization Laboratory (NCL). One of the material file example highlights NCL-23, from the NCL200612 study, a name that identifies a material characterized by the NCL. This example indicates that the sample NCL-23 is a complex formed out of NCL-22 (a G4.5 PAMAM dendrimer terminated with carboxyl groups) and NCL-24 (magnevist), each of which are described in a separate Material File shown in the Material File Examples wiki page.

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