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Attendees



Discussion items

ItemWhoNotes
IntroductionsTodd
  • Introducing Gina Kuffel
Committee GoalsTodd
  • Best Practices publication
    • Initial Outline on Box: https://nih.app.box.com/folder/137612017625
    • Elaine to potentially take the lead on this initiative
    • A milestone driven outline with dates and assigned tasks is needed
    • Set to begin work on this effort by mid August
    • Target date for submission is October 1, 2021
  • Variant filter file
    • Some of the filters are not well understood by the group
    • A discussion is needed to identify overlap and differences in variant calling filter files being using by various groups
    • Dependent on genome best practices for calling germ-line mutations
OtherTodd

Next meeting: Cancel August 17th?  Following meeting is September 21st.

  • We will meet on August 17th

Minutes (Not Verbatim)

JT- Happy to give Elaine a call to confirm she would like to take the lead on drafting the Best Practices publication come mid-August

...

PJ- The outline is a series of items that need to be added in order to amplify the paper.

CL- The people that are invloved involved in the existing white paper, should they be driving the process?

...

CL- What is the target date for submission?

JT- October 1, 2021

TP- Did we want to take a similar approach to the variant filter file? Who will be involved? Who will lead it? Right now everyone is using a different version of a variant calling filter file, the goal is to create a universal variant calling filter file.

AL- Is there a way to come up with a unified reference genome? Can we decide which genome should be used?

HG- Each group has their own vcf filter file. I suspect there to be overlap, but we should come together and discuss the differences.

DD- It can be a bit of a moving target. We use a vcf file mostly based off the one Elaine has posted. Some of the filters are not well understood by the group.

SZ- Curating a resource would be valuable in order to decipher between somatic and germ-line mutations. This is dependent on genome best practices on how to call germ-line mutations.


Action items

  •  Unknown User (hechtt) to share paper about canine reference genomes
  •  Jeff Trent to confirm that  Elaine is willing to take the lead on generating an outline for amplifying the white paper in preparation for publication.