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Anju Singh
Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Pihl, Todd (NIH/NCI) [C]

X
Unknown User (leblancak)

X

Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]
X

Sommers, Connie (NIH/NCI) [E]

X
Debbie KnappX
Toby HechtX

Unknown User (parchmentr)

X

Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

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https://nih.box.com/s/5wmrgl85z6fxpo3ldhanxzmmqq3ekfy7

Relevant Links for Today's Meeting

  1. Candidate Publication List
  2. Submission Folder for 1st Candidate Publication
  3. Submission Folder for PanCancer Study
  4. Data Transfer Agreement
  5. Data Use Guidelines

Outstanding Action Items

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ItemWhoTalking Points
Steering Committee Meeting UpdatesUnknown User (parchmentr)ICDC Site Updates

Kuffel, Gina (NIH/NCI) [C]

  • Last meeting was Nov. 17th
  • Next meeting is
Production release targeted for
  • Dec. 15th
New slide deck available (if we want to spend the time talking about features)
  • Will ask for volunteers to have a brain storming session for ICDC research questions
ICDC Next Phase

Unknown User (hechtt)

DGAB Updates

Kuffel, Gina (NIH/NCI) [C]

  • Updates to existing studies
    • GLIOMA01- 77 case-level vcf and 77 tbi files added (80.2 MB)
  • New studies released
    • MGT01- Molecular Homology and Differences Between Spontaneous Canine Mammary Cancer and Human Breast Cancer (68 files, 289.3 GB)
    • C0TC022- A Contemporaneous Controlled Study of the Standard of Care in Dogs with Appendicular Osteosarcoma (2 files, 0.08 MB)
  • Communications with authors of first candidate publication test case from Candidate Publication List
    • Data Submission Request was completed on their behalf
    • Email was sent by Warren Kibbe on behalf of DGAB
    • Folder containing all submission artifacts for this test case can be found here
  • Data ingestion PanCancer study to begin soon
    • Folder containing all submission artifacts for this study can be found here
  • Data Transfer Agreement is in final stages of legal approval
    • Folder containing any artifacts related to the DTA can be found here
Data Use Guidelines

Kuffel, Gina (NIH/NCI) [C] 

  • Sent to Jason Cristofaro for review
  • Questions remain around the commercial use of the data
  • Link to draft document can be found here
User Research for ICDC by the Office of Communications and Public Liaison (OCPL)Kuffel, Gina (NIH/NCI) [C] 
  • In kick-off and planning phase
  • Finalizing user interview dates: The UX company is targeting January or early February
  • Google Analytics reports have been shared with the UX contractor for their discovery period
  • Recruitment is critical- these will be folks targeted for user interviews
    • DGAB members
    • PRECINCT members
    • Pharmacodynamics group
    • Other groups, channels, or individuals?
ICDC Site Updates

Kuffel, Gina (NIH/NCI) [C]

  • Production release targeted for Dec. 15th
  • New slide deck available (if we want to spend the time talking about features)

Minutes (Not Verbatim)

EK - Collected use cases in 2019 before any data was in ICDC. Around 8 use cases were documented. Many of the responses included high-level, overarching concepts. To uncover the real scientific use cases we nee do talk with PostDcos and Grad Students.

TH- Comparative Oncology community will be interested in specific questions.

EK- NCPI has a team comprised of NHLBI, NCI, Common Fund, and NHGRI to provide use cases of interoperability across the platforms and cloud resources. We are exploring congenital cancer in Gliomas, we might be able to add canine glioma data to identify any correlations that may exist. Use cases are in the works. We solicited researchers to get the scientific use cases.

TH- Longitudinal studies can be very useful in dogs. We can use that data to draw comparisons in humans. We will probably give some funding to the Dog Aging Study that may be matched by the Dog Aging Institute. They have ~30k dogs they are following, healthy dogs, many develop cancer. They are willing to sequence if they had the funding.

JO- Valuable just to have healthy, normal dogs as well. Could they be a source for deposit into ICDC?

TH- Reference standards are prolific at this point. There is a new canine reference German Shepherd 1.0 named Mischka.

Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

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