Page History
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Note: These collections have been migrated to The Cancer Imaging Archive (TCIA) with the exception of RIDER Pilot. Visit the TCIA RIDER Collections wiki page to learn more. |
Summary
The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):
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This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated.
Pilot Statistics | Value |
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Modalities | CT, DX |
Number of Patients | 322 |
Number of Studies | 1,779 |
Number of Series | 4,931 930 |
Number of Images | 384,536 535 |
RIDER Contracts (2007-Beyond)
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- Develop a consensus on requirements for quantity assurance methods for longitudinal studies using phantom data as applied to each modality above,
- Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised,
- Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies
- Provide access to results of measurements performed on these databases by each academic site to encourage a comparison on methodologies,
- Provide consensus-based juried publications to encourage a broad acceptance of the methods described above.
- Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network QIN): http://grants.nih.gov/grants/guide/pa-files/PAR-08-22511.150.html
The databases are being provided with a timely goal of 18 months time frame, namely from the time the contract was initiated and the published results within less than 2 years. The methods for data collection and analysis including results are described in the new Combined RIDER white Paper Report (Sept 2008): RIDER White Paper: Combined contracts report ( Sept 2008)
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The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-0811-225150.html
ACADEMIC SITE COLLECTIONS: Focus on methods for data analysis
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- Images contained in "RIDER Lung CT" Collection in NBIA
- Repeat CT Measurements: Human subjects: Lung
- Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls
- Download the related publication: Zhaob-RepeatCT Radiology2009.pdf
Lung CT Statistics | Value |
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Modalities | CT |
Number of Patients | 32 |
Number of Studies | 46 |
Number of Series | 64 |
Number of Images | 15,716 |
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- Images contained in "Phantom" Collection in NBIA
- Repeat measurements: PET/CT phantoms
Collection Statistics | Value |
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Modalities | CT, PT |
Number of Patients | 20 |
Number of Studies | 20 |
Number of Series | 60 |
Number of Images | 2,231 |
- Images contained in "RIDER Lung PET CT" Collection in NBIA
- Longitudinal PET/CT human studies: Lung
Lung PET CT Statistics | Value |
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Modalities | CT, PT |
Number of Patients | 244 |
Number of Studies | 275 |
Number of Series | 1350 1349 |
Number of Images | 269,523 522 |
DUKE UNIVERSITY
- Images contained in "RIDER Neuro MRI" Collection in NBIA
- Repeat human subject studies: Neuro
- Dynamic Contract Enhanced studies: DCE MRI:
- Diffusion weighted imaging: DWI MR
- Diffusion tensor imaging: DT MRI.
Neuro MRI Statistics | Value |
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Modalities | MR |
Number of Patients | 19 |
Number of Studies | 108 |
Number of Series | 368 |
Number of Images | 70,220 |
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- Images contained in "RIDER Breast MRI" Collection in NBIA
- Repeat measurements: Human subjects: Breast
- DCE MRI
- ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.
Breast MRI Statistics | Value |
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Modalities | MR |
Number of Patients | 5 |
Number of Studies | 10 |
Number of Series | 40 |
Number of Images | 2,400 |
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- Images contained in "RIDER Phantom MRI" Collection in NBIA
- Repeat measurement: Phantom studies
- DCE MRI
- .pdf
provides a summary of the images in this collection.
- .pdf
provides a key for understanding their presentation in NBIA.
Phantom MRI Statistics | Value |
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Modalities | MR |
Number of Patients | 10 |
Number of Studies | 13 |
Number of Series | 45 |
Number of Images | 7,061 |
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- NIST has NCI NBIA data and data from other data sources
- See Biochange 2008
- http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm
Data Access
You can view and download these images on NBIA. You do not need to log in unless you want access to advanced features in the site. Simply follow these steps:
- Navigate to http://imaging.nci.nih.gov
- Click the "Search Images" link in the center of the page
- Scroll down through the search criteria until you see the "Collections" section
- Select the check box for whichever RIDER sub-collection you are interested in
- Press "Submit"
This will return the full list of cases included in the collection. To download the associated DICOM images:
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