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Reference Image Database to Evaluate Therapy Response (RIDER)

1. Executive Summary

The RIDER database is a targeted data collection for the purpose of generating a broad an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the the first RIDER white paper paper report (2006):

All the image data is are DICOM compliant and the image, annotations and meta data formats meets all the requirements for caBIG and the NBIA.  The data collection has two phases as described below.

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2. RIDER PILOT PROJECT (2005-2007)

This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated. However it contains a sub-set of 30 longitudinal cases that are annotated using the RECIST criteria.

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3. RIDER Contracts: 2007-Beyond

NCI has exercised a series of contracts with specific academic sites for collection of repeat "coffee break" and longitudinal phantom and patient data for a range of imaging modalities (currently CT, PET CT, DCE MRI, DW MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:

  1. Develop a consensus on requirements for quantity assurance methods for longitudinal studies using phantom data as applied to each modality above,
  2. Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised,
  3. Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies
  4. Provide access to results of measurements performed on these databases by each academic site , performed under the contract where appropriate, to encourage a comparison on methodologies,
  5. Provide consensus-based juried publications to encourage a broad acceptance of the methods described above. Anticipated publication date July-Aug 2009..
  6. Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network QIN): http://grants.nih.gov/grants/guide/pa-files/PAR-08-225.html


The databases are being provided within an 18 month with a timely goal of 18 months time frame, namely from the time the contract was initiated and the published results within less than 2 years.
 

Academic Site Collections

MSKCC

  • 32 cases, each with 2 series of Lung CT Repeat Patient data.
  • Status (5-05-09): Brian working with contact who is submitting with CTP from MSKCC

UWASH

  • Repeat measurements (Coffee break) PET/CT phantoms
    • Accrual completed, images stored in NBIA
    • 20 cases in total added in July of 2007
    • Stored separately from the RIDER collection in NBIA.  These cases are actually found in the Phantom collection.
  • Longitudinal lung PET/CT patient studies
    • Accrual completed, images stored in NBIA
    • 265 cases in total added in May of 2009

Duke

  • DCE MRI for neuro.
  • Diffusion weighted imaging DWI MR (neuro).
  • Diffusion tensor imaging  (neuro).
  • 4.14 GB (211mb non-dicom) on CBIIT FTP site as of 1/16/09.
  • Status (5-05-09) NCICB will submit to NBIA later in May (on NBIA 2.4)

Michigan

  • Coffee Break
  • 96 MB on FTP Site as of 1/16/09.
  • Number of cases expected = 5 cases, 2 studies each case of breast DCE MR
  • Undetermined submission strategy.
  • Status (5-05-09) Brian Hughes is following up for total of 10 cases (approx?)

MDACC

  • Dynamic MRI patient studies.
  • 758mb on hand as of 1/16/09.
  • Undetermined submission strategy.

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Other Government and Society Collections

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RSNA QIBA

  • CT phantom studies (built by NCI/RIDER contract with Ed Jackson, MDACC)
  • Dynamic MRI (DCMRI) phantom.
  • Data to be submitted via CTP from 5 sites to be downloaded and annotated by VirtualScopics

FDA

 
The methods for data collection and analysis including results are described in the new Combined RIDER white Paper Report (Sept 2008)


The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: ): http://grants.nih.gov/grants/guide/pa-files/PAR-08-225.html

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3.1 ACADEMIC SITE COLLECTIONS: Focus on methods for data analysis

MSKCC

  • Repeat CT Measurements: Human subjects: Lung

 UNIVERSITY OF WASHINGTON

  • Repeat measurements: PET/CT phantoms
  • Longitudinal PET/CT human studies: Lung

DUKE UNIVERSITY

  • Repeat human subject studies: Neuro
  • Dynamic Contract Enhanced studies: DCE MRI:
  • Diffusion weighted imaging: DWI MR
  • Diffusion tensor imaging: DT MRI.

UNIVERSITY OF MICHIGAN

  • Repeat measurements: Human subjects: Breast
  • DCE MRI

MDACC

  • Repeat measurement: Human studies: Neuro and Liver
  • DCE MRI
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3.2 ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection.
MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)
Repeat measurements
Diffusion Weighted Imaging (DWI)
Phantom measurements
Human subjects
White Paper: http://www.neoplasia.com/pdf/manuscript/v11i02/neo081328.pdf




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4. SOCIETY DATA COLLECTIONS

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RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)

5. OTHER FEDERAL AGENCIES
FDA CDRH: Partly funded by NCI and NIBIB

  • 1000 to 1500 phantom images by end of 1000 to 1500 phantom images by Sept 2009.
  • Collection exists w/ 3 cases on NCIA (Phantom-FDA).
  • Will provide hard drive containing images to CBIIT.
  • Brian Hughes waiting for contact to give him a harddrive (5-05-09)
  • Brian received hard drive 5/27/09
  • Data being stored in the Phantom-FDA collection

NIST