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Some |
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significant |
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examples |
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of |
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collaborations |
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and |
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use |
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of |
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EVS |
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resources |
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and |
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services |
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are |
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briefly |
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outlined |
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in |
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this |
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section |
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covering |
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NCI, |
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and |
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in |
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later |
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sections |
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covering |
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NIH, |
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government |
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and |
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standards |
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organizations, |
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and |
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other |
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organizations |
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in |
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the |
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cancer |
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research |
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and |
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biomedical |
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community. |
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This |
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section |
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includes |
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the |
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following |
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NCI profiles: |
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NCI Division of Cancer Biology (DCB) |
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EVS |
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has |
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supported |
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DCB |
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research |
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on |
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mouse |
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and |
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other |
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animal |
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models |
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of |
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cancer |
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for |
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more |
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than |
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10 |
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years. |
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EVS |
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has |
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helped |
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develop |
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and |
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maintain |
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accurate |
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coding |
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and |
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classification |
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terminology |
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for |
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animal |
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models, |
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and |
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has |
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worked |
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with |
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NCI |
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and |
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community |
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partners |
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to |
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develop |
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accurate |
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mappings |
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between |
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terminologies |
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currently |
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in |
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use. |
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Key |
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NCI |
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components |
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of |
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this |
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effort |
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are |
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described |
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here, |
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while |
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community |
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partners |
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are |
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described |
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later |
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. |
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Mouse |
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Models |
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of |
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Human |
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Cancer |
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Consortium |
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(MMHCC) |
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was |
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established |
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by |
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NCI |
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in |
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1999 |
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to |
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accelerate |
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the |
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development |
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and |
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validation |
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of |
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mouse |
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models |
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by |
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the |
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scientific |
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community. |
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When |
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the |
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MMHCC |
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was |
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initiated, |
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one |
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of |
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the |
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early |
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projects |
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was |
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to |
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create |
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a |
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repository |
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of |
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curated |
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information |
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about |
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animal |
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models |
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that |
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have |
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been |
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employed |
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in |
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cancer |
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studies, |
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called |
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the |
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Cancer |
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Models |
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Database |
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(now |
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caMOD |
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). |
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EVS |
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staff |
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participated |
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in |
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developing |
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the |
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classifications |
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of |
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mouse |
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diagnoses |
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used |
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for |
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annotating |
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the |
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mouse |
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models, |
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and |
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provided |
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support |
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for |
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additional |
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terminology |
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such |
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as |
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strains |
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and |
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anatomy. |
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All |
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of |
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this |
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terminology |
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has |
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been |
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incorporated |
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into |
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NCI |
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Thesaurus |
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(NCIt), |
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used |
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by |
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caMOD |
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and |
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other |
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users |
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through |
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both |
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browser |
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and |
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programming |
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interfaces. |
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caMOD |
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annotates |
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information |
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with |
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NCIt |
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terminology, |
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and |
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uses |
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the |
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LexEVS |
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API |
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directly |
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to |
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generate |
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anatomy |
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and |
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diagnosis |
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tree |
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hierarchies. |
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400 |
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concepts |
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were |
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added |
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or |
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updated |
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for |
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caMOD |
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in |
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the |
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last-recorded |
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six |
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month |
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period. |
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EVS |
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has |
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supported |
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periodic |
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updates |
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to |
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this |
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animal |
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model |
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terminology, |
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and |
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has |
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extended |
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terminology |
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support |
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to |
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cover |
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rats |
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and |
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zebrafish, |
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using |
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existing |
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community |
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standards |
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where |
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available: |
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MMHCC has merged with the Mouse Repository at Frederick National Research Laboratories, which provides mouse cancer models and associated strains, live and cryopreserved. Additional future support for updating the diagnosis terminology to reflect new models is anticipated. For more information, visit the NCI eMICE website. EVS Related References
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NCI Division of Cancer Control and Population Sciences (DCCPS)DCCPS collaboration includes several terminology projects related to cancer classification, drugs, chemotherapy regimens, and statistics. DCCPS is currently launching a new initiative on standardized terminology for population health data collection. Portfolio Management Application (PMA-DCCPS) |
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: |
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EVS |
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has |
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worked |
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with |
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DCCPS |
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for |
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a |
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number |
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of |
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years |
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to |
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integrate |
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PMA-DCCPS |
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grant |
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coding |
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terminology |
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with |
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other |
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EVS |
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resources. |
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NCIt |
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now |
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includes |
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more |
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than |
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1,500 |
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concepts |
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for |
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PMA |
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grant |
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coding. |
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PMA |
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terms |
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are |
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also |
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inserted |
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and |
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appear |
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in |
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the |
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NCI |
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Metathesaurus |
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as |
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a |
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separate |
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terminology. |
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NCI |
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Division |
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of |
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Cancer |
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Prevention |
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(DCP) |
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DCP |
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has |
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used |
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EVS, |
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and |
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worked |
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consistently |
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with |
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EVS, |
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since |
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2002, |
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including |
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the |
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following |
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collaborations |
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and |
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uses: |
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NCI |
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DCP |
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and |
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DCTD |
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EVS |
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staff |
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provides |
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terminology |
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support |
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for |
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the |
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Community |
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Clinical |
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Oncology |
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Program |
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(CCOP), |
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including |
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concepts |
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for |
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use |
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in |
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coding |
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four |
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(4) |
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major |
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clinical |
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trials |
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involving |
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85,000 |
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patients. |
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An |
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estimated |
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total |
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of |
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500 |
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studies |
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use |
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NCI |
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Thesaurus |
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terminology. |
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NCI |
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Division |
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of |
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Cancer |
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Treatment |
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and |
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Diagnosis |
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(DCTD) |
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Cancer |
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Therapy |
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Evaluation |
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Program |
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(CTEP) |
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The |
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Cancer |
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Therapy |
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Evaluation |
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Program |
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(CTEP) |
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has |
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had |
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many |
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and |
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sustained |
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collaborations |
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with |
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EVS |
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from |
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1999 |
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onwards, |
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including: |
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Common |
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Terminology |
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Criteria |
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for |
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Adverse |
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Events |
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(CTCAE) |
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CTCAE, |
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created |
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by |
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CTEP |
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in |
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1983, |
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is |
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used |
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throughout |
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the |
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entire |
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oncology |
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community |
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as |
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the |
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standard |
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classification |
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and |
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severity |
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grading |
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scale |
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for |
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adverse |
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events |
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in |
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cancer |
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therapy |
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clinical |
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trials |
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and |
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other |
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oncology |
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settings. |
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It |
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is |
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also |
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used |
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in |
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a |
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number |
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of |
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non-oncology |
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trials |
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and |
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settings. |
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Version |
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4, |
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released |
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in |
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May |
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2009, |
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is |
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a |
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major |
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update |
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based |
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on |
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extensive |
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international |
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participation |
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by |
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stakeholders |
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and |
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experts. |
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It |
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is |
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harmonized |
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with |
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MedDRA |
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at |
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the |
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Adverse |
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Event |
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(AE) |
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level, |
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includes |
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revised |
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AE |
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terms |
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and |
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severity |
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indicators |
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to |
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reflect |
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clinical |
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effects |
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identified |
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with |
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current |
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oncology |
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interventions, |
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and |
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was |
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selected |
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as |
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a |
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caBIG® |
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vocabulary |
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standard. |
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This |
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version |
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is |
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used |
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by |
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more |
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than |
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50 |
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academic |
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and |
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research |
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organizations, |
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as |
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well |
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as |
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many |
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commercial |
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and |
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non-profit |
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organizations. |
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Five |
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different |
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Apple |
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applications |
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utilize |
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the |
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NCI |
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Thesaurus |
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version |
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of |
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the |
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CTCAE |
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data, |
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and |
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cite |
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NCIt |
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as |
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the |
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source. |
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CTCAE |
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is |
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designed |
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to |
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integrate |
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into |
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information |
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networks |
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for |
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safety |
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data |
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exchange, |
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and |
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plays |
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a |
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major |
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role |
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in |
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data |
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management for |
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AE |
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data |
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collection, |
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analysis, |
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and |
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patient |
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outcomes |
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associated |
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with |
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cancer |
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research |
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and |
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care. |
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EVS |
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played |
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a |
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central |
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role |
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in |
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designing |
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and |
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managing |
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this |
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effort, |
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working |
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closely |
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with |
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CTEP, |
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DCP, |
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caBIG®, |
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the |
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FDA, |
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and |
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many |
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participants |
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from |
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the |
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broader |
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community. |
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The |
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revision |
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was |
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developed |
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and |
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deployed |
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using |
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various |
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EVS |
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tools |
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including |
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the |
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BiomedGT |
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Wiki, |
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Protégé |
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editing |
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tools, |
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LexEVS |
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terminology |
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server, |
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NCI |
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Term |
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Browser, |
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and |
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the |
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. Cancer Diagnosis Program (CDP) - Diagnostics Evaluation Branch
EVS Related References
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NCI Division of Extramural Activities (DEA)DEA is supported by EVS, which helps collect, develop and map grant-related terminology, including representing NCI in the NIH Research, Condition and Disease Categorization (RCDC) effort. NCI Office of Communications and Education (OCE)OCE co-managed EVS with CBIIT until late 2007, and has continued as an important partner since that time. Some key areas of ongoing collaboration are:
EVS Related References
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Other NCI User ProfilesCooperative Human Tissue Bank (CHTB): EVS has supported terminology creation and editing for this network of research institutions, established by the NCI Cancer Diagnosis Program in 1987 and now including six divisions located at Vanderbilt, U. Penn, UAB School of Medicine, Nationwide Children's Hospital, Ohio State, University of Virginia. CHTB hosts NCI funded tissue facilities and services providing remnant human tissue and fluids from routine procedures to investigators. There is active use by 14 academic and research organizations and eight (8) commercial organizations. EVS staff assisted with matching up terminology used by these groups to NCIt terminology, creating new NCIt concepts and definitions as needed. Cancer Central Clinical Database (C3D): EVS provides support for C3D, largely through providing the new and updated terminology and definitions for case report forms. C3D currently supports electronic submission of clinical trials data to the NCI Clinical Data System (CDS) and the Clinical Trials Monitoring Service (CTMS/Theradex). OPEN (Oncology Patient Enrollment Network): This web-based registration system for patient enrollments onto NCI-sponsored Cooperative Group clinical trials is a highly active project; most terminology supplied for this is standard demographic terminology. |
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