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title
title

 

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Multiexcerpt
MultiExcerptNameUserProfiles-NCI

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Some

...

significant

...

examples

...

of

...

collaborations

...

and

...

use

...

of

...

EVS

...

resources

...

and

...

services

...

are

...

briefly

...

outlined

...

in

...

this

...

section

...

covering

...

NCI,

...

and

...

in

...

later

...

sections

...

covering

...

NIH,

...

government

...

and

...

standards

...

organizations,

...

and

...

other

...

organizations

...

in

...

the

...

cancer

...

research

...

and

...

biomedical

...

community.

...

This

...

section

...

includes

...

the

...

following

...

NCI profiles:

...

Table of Contents

...

minLevel

...

2

NCI Division of Cancer Biology (DCB)

...

EVS

...

has

...

supported

...

DCB

...

research

...

on

...

mouse

...

and

...

other

...

animal

...

models

...

of

...

cancer

...

for

...

more

...

than

...

10

...

years.

...

EVS

...

has

...

helped

...

develop

...

and

...

maintain

...

accurate

...

coding

...

and

...

classification

...

terminology

...

for

...

animal

...

models,

...

and

...

has

...

worked

...

with

...

NCI

...

and

...

community

...

partners

...

to

...

develop

...

accurate

...

mappings

...

between

...

terminologies

...

currently

...

in

...

use.

...

Key

...

NCI

...

components

...

of

...

this

...

effort

...

are

...

described

...

here,

...

while

...

community

...

partners

...

are

...

described

...

later

...

14

...

-

...

User

...

Profiles

...

-

...

Broader

...

Community

...

.

...

Mouse

...

Models

...

of

...

Human

...

Cancer

...

Consortium

...

(MMHCC)

...

was

...

established

...

by

...

NCI

...

in

...

1999

...

to

...

accelerate

...

the

...

development

...

and

...

validation

...

of

...

mouse

...

models

...

by

...

the

...

scientific

...

community.

...

When

...

the

...

MMHCC

...

was

...

initiated,

...

one

...

of

...

the

...

early

...

projects

...

was

...

to

...

create

...

a

...

repository

...

of

...

curated

...

information

...

about

...

animal

...

models

...

that

...

have

...

been

...

employed

...

in

...

cancer

...

studies,

...

called

...

the

...

Cancer

...

Models

...

Database

...

(now

...

caMOD

...

).

...

EVS

...

staff

...

participated

...

in

...

developing

...

the

...

classifications

...

of

...

mouse

...

diagnoses

...

used

...

for

...

annotating

...

the

...

mouse

...

models,

...

and

...

provided

...

support

...

for

...

additional

...

terminology

...

such

...

as

...

strains

...

and

...

anatomy.

...

All

...

of

...

this

...

terminology

...

has

...

been

...

incorporated

...

into

...

NCI

...

Thesaurus

...

(NCIt),

...

used

...

by

...

caMOD

...

and

...

other

...

users

...

through

...

both

...

browser

...

and

...

programming

...

interfaces.

...

caMOD

...

annotates

...

information

...

with

...

NCIt

...

terminology,

...

and

...

uses

...

the

...

LexEVS

...

API

...

directly

...

to

...

generate

...

anatomy

...

and

...

diagnosis

...

tree

...

hierarchies.

...

400

...

concepts

...

were

...

added

...

or

...

updated

...

for

...

caMOD

...

in

...

the

...

last-recorded

...

six

...

month

...

period.

...

EVS

...

has

...

supported

...

periodic

...

updates

...

to

...

this

...

animal

...

model

...

terminology,

...

and

...

has

...

extended

...

terminology

...

support

...

to

...

cover

...

rats

...

and

...

zebrafish,

...

using

...

existing

...

community

...

standards

...

where

...

available:

...

  • International

...

  • Harmonization

...

  • of

...

  • Rat

...

  • Nomenclature

...

  • (RENI)

...

  • was

...

  • used

...

  • as

...

  • the

...

  • foundation

...

  • for

...

  • the

...

  • Terminology

...

  • of

...

  • Rat

...

  • Pathologic

...

  • Diagnoses

...

  • in

...

  • NCI

...

  • Thesaurus

...

  • (NCIt).

...

  • Zebrafish

...

  • Information

...

  • Network

...

  • (ZFIN)

...

  • zebrafish

...

  • anatomy

...

  • is

...

  • provided

...

  • as

...

  • a

...

  • standalone

...

  • terminology

...

  • in

...

  • EVS

...

  • systems

...

  • including

...

  • the

...

...

...

...

  • .

MMHCC has merged with the Mouse Repository at Frederick National Research Laboratories, which provides mouse cancer models and associated strains, live and cryopreserved. Additional future support for updating the diagnosis terminology to reflect new models is anticipated.

For more information, visit the NCI eMICE website.

EVS Related References

  1. Bodenreider O, Hayamizu TF, Ringwald M, De Coronado S, Zhang S.
    Of mice and men: aligning mouse and human anatomies.
    AMIA Annu Symp Proc. 2005:61-5.

...

  1. PubMed

...

  1. PMID:

...

  1. 16779002;

...

  1. PubMed

...

  1. Central

...

  1. PMCID:

...

  1. PMC1560846.

...

  1. [PubMed

...

  1. ]
  2. Hayamizu TF, de Coronado S, Fragoso G, Sioutos N, Kadin JA, Ringwald M.
    The mouse-human anatomy ontology mapping project.
    Database (Oxford). 2012 Mar 20;2012:bar066.

...

  1. Print

...

  1. 2012.

...

  1. PubMed

...

  1. PMID:

...

  1. 22434834.

...

  1. [PubMed

...

  1. ] [Full Text]
  2. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
    Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
    Blood. 2002 Jul 1;100(1):238-45.

...

  1. PubMed

...

  1. PMID:

...

  1. 12070033.

...

  1. [PubMed]

NCI Division of Cancer Control and Population Sciences (DCCPS)

DCCPS collaboration includes several terminology projects related to cancer classification, drugs, chemotherapy regimens, and statistics. DCCPS is currently launching a new initiative on standardized terminology for population health data collection.

Portfolio Management Application (PMA-DCCPS)

...

:

...

EVS

...

has

...

worked

...

with

...

DCCPS

...

for

...

a

...

number

...

of

...

years

...

to

...

integrate

...

PMA-DCCPS

...

grant

...

coding

...

terminology

...

with

...

other

...

EVS

...

resources.

...

NCIt

...

now

...

includes

...

more

...

than

...

1,500

...

concepts

...

for

...

PMA

...

grant

...

coding.

...

PMA

...

terms

...

are

...

also

...

inserted

...

and

...

appear

...

in

...

the

...

NCI

...

Metathesaurus

...

as

...

a

...

separate

...

terminology.

...

NCI

...

Division

...

of

...

Cancer

...

Prevention

...

(DCP)

...

DCP

...

has

...

used

...

EVS,

...

and

...

worked

...

consistently

...

with

...

EVS,

...

since

...

2002,

...

including

...

the

...

following

...

collaborations

...

and

...

uses:

...

  • Use

...

  • of

...

  • NCIt

...

  • agent

...

  • information

...

  • in

...

  • DCP

...

  • systems.

...

  • Joint

...

  • work

...

  • on

...

  • improved

...

  • coverage

...

  • of

...

  • nutritional

...

  • and

...

  • other

...

  • preventive

...

  • agents.

...

  • Joint

...

  • work

...

  • in

...

  • wider

...

  • working

...

  • groups

...

  • and

...

  • other

...

  • initiatives

...

  • to

...

  • harmonize

...

  • broader

...

  • NCI

...

  • agent

...

  • coding

...

  • practices.

...

NCI

...

DCP

...

and

...

DCTD

...

EVS

...

staff

...

provides

...

terminology

...

support

...

for

...

the

...

Community

...

Clinical

...

Oncology

...

Program

...

(CCOP),

...

including

...

concepts

...

for

...

use

...

in

...

coding

...

four

...

(4)

...

major

...

clinical

...

trials

...

involving

...

85,000

...

patients.

...

An

...

estimated

...

total

...

of

...

500

...

studies

...

use

...

NCI

...

Thesaurus

...

terminology.

...

NCI

...

Division

...

of

...

Cancer

...

Treatment

...

and

...

Diagnosis

...

(DCTD)

...

Cancer

...

Therapy

...

Evaluation

...

Program

...

(CTEP)

...

The

...

Cancer

...

Therapy

...

Evaluation

...

Program

...

(CTEP)

...

has

...

had

...

many

...

and

...

sustained

...

collaborations

...

with

...

EVS

...

from

...

1999

...

onwards,

...

including:

...

  • Use

...

  • of

...

  • NCI

...

  • Thesaurus

...

  • (NCIt)

...

  • terminology

...

  • for

...

  • protocol

...

  • abstraction.

...

  • Harmonization

...

  • and

...

  • use

...

  • of

...

  • NCIt

...

  • drug

...

  • and

...

  • molecular

...

  • target

...

  • information

...

  • in

...

  • CTEP

...

  • systems.

...

  • Harmonization

...

  • and

...

  • integration

...

  • of

...

  • CTEP

...

  • disease

...

  • classification

...

  • with

...

  • NCIt,

...

  • PDQ

...

  • and

...

  • MedDRA,

...

  • involving

...

  • several

...

  • detailed

...

  • comparative

...

  • mappings

...

  • and

...

  • analyses

...

  • as

...

  • well

...

  • as

...

  • concept

...

  • based

...

  • mappings

...

  • in

...

  • the

...

  • NCI

...

  • Metathesaurus

...

  • (NCIm).

...

  • Joint

...

  • development,

...

  • together

...

  • with

...

  • other

...

  • partners,

...

  • of

...

  • the

...

  • redesigned

...

  • Common

...

  • Terminology

...

  • Criteria

...

  • for

...

  • Adverse

...

  • Events

...

  • (CTCAE)

...

  • v.4,

...

  • which

...

  • has

...

  • been

...

  • widely

...

  • adopted

...

  • since

...

  • its

...

  • release

...

  • in

...

  • 2010

...

  • (see

...

  • the

...

  • detailed

...

  • description

...

  • below).

...

Common

...

Terminology

...

Criteria

...

for

...

Adverse

...

Events

...

(CTCAE)

...

CTCAE,

...

created

...

by

...

CTEP

...

in

...

1983,

...

is

...

used

...

throughout

...

the

...

entire

...

oncology

...

community

...

as

...

the

...

standard

...

classification

...

and

...

severity

...

grading

...

scale

...

for

...

adverse

...

events

...

in

...

cancer

...

therapy

...

clinical

...

trials

...

and

...

other

...

oncology

...

settings.

...

It

...

is

...

also

...

used

...

in

...

a

...

number

...

of

...

non-oncology

...

trials

...

and

...

settings.

...

Version

...

4,

...

released

...

in

...

May

...

2009,

...

is

...

a

...

major

...

update

...

based

...

on

...

extensive

...

international

...

participation

...

by

...

stakeholders

...

and

...

experts.

...

It

...

is

...

harmonized

...

with

...

MedDRA

...

at

...

the

...

Adverse

...

Event

...

(AE)

...

level,

...

includes

...

revised

...

AE

...

terms

...

and

...

severity

...

indicators

...

to

...

reflect

...

clinical

...

effects

...

identified

...

with

...

current

...

oncology

...

interventions,

...

and

...

was

...

selected

...

as

...

a

...

caBIG®

...

vocabulary

...

standard.

...

This

...

version

...

is

...

used

...

by

...

more

...

than

...

50

...

academic

...

and

...

research

...

organizations,

...

as

...

well

...

as

...

many

...

commercial

...

and

...

non-profit

...

organizations.

...

Five

...

different

...

Apple

...

applications

...

utilize

...

the

...

NCI

...

Thesaurus

...

version

...

of

...

the

...

CTCAE

...

data,

...

and

...

cite

...

NCIt

...

as

...

the

...

source.

...

CTCAE

...

is

...

designed

...

to

...

integrate

...

into

...

information

...

networks

...

for

...

safety

...

data

...

exchange,

...

and

...

plays

...

a

...

major

...

role

...

in

...

data

...

management for

...

AE

...

data

...

collection,

...

analysis,

...

and

...

patient

...

outcomes

...

associated

...

with

...

cancer

...

research

...

and

...

care.

...

EVS

...

played

...

a

...

central

...

role

...

in

...

designing

...

and

...

managing

...

this

...

effort,

...

working

...

closely

...

with

...

CTEP,

...

DCP,

...

caBIG®,

...

the

...

FDA,

...

and

...

many

...

participants

...

from

...

the

...

broader

...

community.

...

The

...

revision

...

was

...

developed

...

and

...

deployed

...

using

...

various

...

EVS

...

tools

...

including

...

the

...

BiomedGT

...

Wiki,

...

Protégé

...

editing

...

tools,

...

LexEVS

...

terminology

...

server,

...

NCI

...

Term

...

Browser,

...

and

...

the

...

EVS

...

ftp

...

site

...

.

Cancer Diagnosis Program (CDP) - Diagnostics Evaluation Branch

  • EVS is supporting gene nomenclature used in a new CDP Biomarker project, including updating Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) terminology in the EVS servers so it is accessible to CDP curators. See HGNC on NCI Term Browser.
  • In an extension to this project, EVS will be creating gene and protein sequence variations in the NCIt, according to HGVS guidelines, for genes/proteins of therapeutic interest as requested by CDP. The initial request is 150 genes (in progress), with about 180 protein variants, 300 gene variants, 300 fusion genes, and 300 fusion proteins.
  • This work is to support creation of an application to retrieve content from the NIH Clinical Trial Database into the NCI Clinical Trials Reporting Program (CTRP), and is being done jointly with DCTD, NCI/OCE, NCI/CCR and NIH/NLM.

EVS Related References

  1. Chen AP, Setser A, Anadkat MJ, Cotliar J, Olsen EA, Garden BC, Lacouture ME.
    Grading dermatologic adverse events of cancer treatments: the Common Terminology Criteria for Adverse Events Version 4.0.
    J Am Acad Dermatol. 2012 Nov;67(5):1025-39.

...

  1. doi:

...

  1. 10.1016/j.jaad.2012.02.010.

...

  1. Epub

...

  1. 2012

...

  1. Apr

...

  1. 11.

...

  1. PubMed

...

  1. PMID:

...

  1. 22502948.

...

  1. [PubMed

...

  1. ]
  2. Cimino JJ, Hayamizu TF, Bodenreider O, Davis B, Stafford GA, Ringwald M.
    The caBIG terminology review process.
    J Biomed Inform. 2009 Jun;42(3):571-80.

...

  1. Epub

...

  1. 2008

...

  1. Dec

...

  1. 25.

...

  1. PubMed

...

  1. PMID:

...

  1. 19154797;

...

  1. PubMed

...

  1. Central

...

  1. PMCID:

...

  1. PMC2729758.

...

  1. [PubMed

...

  1. ]

NCI Division of Extramural Activities (DEA)

DEA is supported by EVS, which helps collect, develop and map grant-related terminology, including representing NCI in the NIH Research, Condition and Disease Categorization (RCDC) effort.

NCI Office of Communications and Education (OCE)

OCE co-managed EVS with CBIIT until late 2007, and has continued as an important partner since that time. Some key areas of ongoing collaboration are:

  • PDQ Terminology has been used for decades to code cancer clinical trials and other NCI scientific and public information resources, including NCI's Clinical Trials Reporting Program (CTRP) initiative. EVS has used PDQ terminology as a core component of its NCI Thesaurus (NCIt) reference terminology, and has worked to harmonize with and add to PDQ terminology even as NCIt was extended in many ways not required for PDQ itself. EVS took over and carries on efforts to harmonize and cross-link both PDQ terminology and NCIt with other NCI coding terminologies including CTEP disease and adverse event terminologies, NCI Developmental Therapeutics Program drug terms, and terminology from DCCCPS and DCP. EVS continues to work with OCE on strengthening PDQ terminology as a coding and information retrieval resource. See PDQ on NCI Term Browser and the PDQ to NCIt Mapping.
  • NCI Drug Dictionary provides technical definitions, alternate names, and links to related information for more than 3,000 agents that are being used in the treatment of patients with cancer or cancer-related conditions. Each entry includes a link to a more detailed entry in NCIt, which provides the information presented, as well as links to lists of open and closed cancer clinical trials on NCI's Web site, Cancer.gov. Each month, the NCI Drug Dictionary is used by over 30,000 unique visitors who view more than 65,000 pages.
  • Cancer.gov Database of Cancer Clinical Trials is updated daily and covers over 11,000 clinical trials now accepting participants, plus more than 25,000 others that are no longer recruiting. NCIt drug terminology is used to index PDQ trials, and EVS has contributed to the development of PDQ Terminology used to code cancers and related conditions, procedures, and chemotherapy regimens.
  • NCI Dictionary of Cancer Terms defines more than 7,000 cancer and biomedical terms in non-technical language. Terms and definitions are reviewed by a multidisciplinary panel of reviewers, and approximately 50 new and 50 revised terms are included each month. The dictionary is available as a stand-alone resource on every Cancer.gov Web page, and is widely used by other institutions and Web sites. Its contents are integrated into both NCI Thesaurus and NCI Metathesaurus, providing an important resource especially for non-technical users.

EVS Related References

  1. De Coronado S, Haber MW, Sioutos N, Tuttle MS, Wright LW.
    NCI Thesaurus: Using Science-Based Terminology to Integrate Cancer Research Results.
    Proceedings of the 11th World Congress on Medical Informatics (Medinfo 2004) Amsterdam: IOS Press 2004, pp. 33-37. Also cited as: Stud Health Technol Inform. 2004;107(Pt 1):33-7. [PubMed]
  2. Hubbard SL.
    Information systems in oncology.
    Cancer: Principles & Practice of Oncology, 6th ed. Devita VT, Hellman S, Rosenberg SA, eds. Philadelphia: Lippincott Williams & Wilkins; 2001. pp. 3135–46.
  3. Hubbard SM, Setser A.
    The Cancer Informatics Infrastructure: a new initiative of the National Cancer Institute.
    Semin Oncol Nurs. 2001 Feb;17(1):55-61.

...

  1. Review.

...

  1. PubMed

...

  1. PMID:

...

  1. 11236366.

...

  1. [PubMed

...

  1. ]

...

  1. [Full

...

  1. Text

...

  1. ]
  2. Sioutos N, De Coronado S, Haber MW, Hartel FW, Shaiu WL, Wright LW.
    NCI Thesaurus: A Semantic Model Integrating Cancer-Related Clinical and Molecular Information.
    Journal of Biomedical Informatics 2007 Feb;40(1):30-43.

...

  1. Epub

...

  1. 2006

...

  1. Mar

...

  1. 15.

...

  1. [PubMed

...

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

...

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Other NCI User Profiles

Cooperative Human Tissue Bank (CHTB):  EVS has supported terminology creation and editing for this network of research institutions, established by the NCI Cancer Diagnosis Program in 1987 and now including six divisions located at Vanderbilt, U. Penn, UAB School of Medicine, Nationwide Children's Hospital, Ohio State, University of Virginia. CHTB hosts NCI funded tissue facilities and services providing remnant human tissue and fluids from routine procedures to investigators. There is active use by 14 academic and research organizations and eight (8) commercial organizations. EVS staff assisted with matching up terminology used by these groups to NCIt terminology, creating new NCIt concepts and definitions as needed.

Cancer Central Clinical Database (C3D): EVS provides support for C3D, largely through providing the new and updated terminology and definitions for case report forms. C3D currently supports electronic submission of clinical trials data to the NCI Clinical Data System (CDS) and the Clinical Trials Monitoring Service (CTMS/Theradex).

OPEN (Oncology Patient Enrollment Network): This web-based registration system for patient enrollments onto NCI-sponsored Cooperative Group clinical trials is a highly active project; most terminology supplied for this is standard demographic terminology.

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