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Once you have finished reviewing the gene-compound association in the caBIO Object Graph Browser, return to the caBIO Portlet web browser tab or window, and click the To search for genes associated with these additional compound concepts, return to your Templated Search results page if needed and click the Agent OntologiesAlthough the NCI Thesaurus contains information about compound ontologies, the caBIO Templated Search does not currently allow you to leverage this hierarchical compound information. In the future, this feature may be implemented in this tool, but for now, you must searching the NCI Thesaurus for these ontological compound terms and perform a Templated search for each parent or child concept.
To view compound ontologies, open a new browser tab or window and navigate to the NCI Thesaurus web page, enter in your compound term or NCI Thesaurus concept code (2, "etopo"), and click the Search button (3). If required, select your exact search term from the list to view the NCI Term page. You may view parent and child terms for any disease term by clicking on the Relationships tab (blue box). For example, "Epipodophyllotoxin Compound" has the children "2-Ethylhydrazide," "Etoposide Phosphate," "Etoposide," "GL331," "Podophyllin," and "Teniposide" and the parent terms "Antineoplastic Plant Product ," "ovarian adenocarcinoma," and "Topoisomerase-II Inhibitor ." Alternatively, if you would like to view sister concepts and find where your term fits in the entire agent hierarchy, click the red View in Hierarchy button (green box). |