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The synthetic lung nodules used in our data CT scans were manufactured by either Kyotokagaku Incorporated (Japan) and Computerized Imaging Reference Systems (CIRS, Norfolk, VA). They consisted of objects varying in size (5, 8, 10, 12, 20, 40 mm), shape (spherical, elliptical, lobulated, spiculated), and density (-800, -630, -10, +100 HU). Figure 2 shows examples of the various sizes and shapes of synthetic nodules used in our CT data collection.

 
Figure 2: Photographs of the different types of synthetic nodules used in this study. Each column shows nodules in three sizes, with lobulated, elliptical, speculated, spherical, and complex nodules shown from left to right. The three sizes shown here were manufactured to have the equivalent volumes of spherical nodules with diameters of 5, 10, and 20 mm

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