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Eight different layouts of nodules were specified by placing them in premarked positions within the phantom vasculature, where they were either attached to vessels or suspended in foam (non-attached configuration). Care was taken to maintain constant positioning of the nodules when a particular layout was scanned multiple times or with different protocols. For that purpose, vessels on which nodules were attached were color coded. Table 1 tabulates the nodule configuration for the nodule layouts that are currently available at https://imaging.nci.nih.gov/ncia/login.jsf in terms of nodule positioning, size, shape, and density. Figure 3 shows a schematic diagram of the currently available layouts. All tables and figures in this document will be updated as more data is posted.
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Figure 3. Schematic diagram of Nodule Layout#1 in terms of nodule placement. Vessel branches within the anthropomorphic phantom were color coded for the purpose of mapping nodules to specific positions within the phantom's vasculature structure in a reproducible manner.
The phantom was scanned using a Philips 16-row scanner (Mx8000 IDT, Philips Healthcare, Andover, MA) and a Siemens 64-row scanner (Somatom Definition 64, Siemens Medical Solutions USA, Inc., Malvern, PA). Scans were acquired with varying combinations of effective dose, pitch, and slice collimation, and were reconstructed with varying combinations of slice thicknesses and reconstruction kernels. Ten exposures were acquired for each imaging protocol. The phantom position was not changed during the 10 repeat exposures; however it was repositioned between different imaging protocols or different nodule layouts. Table 2 summarizes the imaging protocols for the nodule layout.

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