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Like ISA-TAB, ISA-TAB-Nano provides fields for entering and referencing terms selected from ontologies and standard terminologies. The ontologies are available at BioPortal (http://www.bioontology.org)
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The Table below represents extensions made to each ISA-TAB file in support of ISA-TAB-Nano.
ISA-TAB Extension Field Name | ISA-TAB File | Purpose |
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Investigation Disease | Investigation | To capture and retrieve investigations associated with specific disease modalities such as cancer |
Investigation Disease Term Accession Number | Investigation | To enable semantic interoperability for disease terms |
Investigation Disease Term Source REF | Investigation | To enable semantic interoperability for disease terms |
Investigation Outcome | Investigation | To enable researchers to review the outcomes of investigations for assessing the utility of the investigation in achieving scientific endpoints |
MATERIAL | Investigation | To allow for the identification of materials used in the investigation and associated studies |
Material File Name | Investigation | To identify the name of the Material File, which lists information about the composition and characteristics of the nanomaterials or other small molecules |
Material Source Name | Investigation | To identify the name of the nanomaterial or small molecule associated with the Material File |
Study Disease | Investigation | To capture and retrieve studies associated with specific disease modalities such as cancer |
Study Disease Term Accession Number | Investigation | To enable semantic interoperability for disease terms |
Study Disease Term Source REF | Investigation | To enable semantic interoperability for disease terms |
Study Outcome | Investigation | To enable researchers to review the outcomes of studies for assessing the utility of the investigation in achieving scientific endpoints |
Study Assay Measurement Name | Investigation | To capture the variables measured in an assay to support cross study analysis |
Study Assay Measurement Name Term Accession Number | Investigation | To enable semantic interoperability for assay measurement names |
Study Assay Measurement Name Term Source REF | Investigation | To enable semantic interoperability for assay measurement names |
Measurement Value | Assay | To record the endpoint value of an assay measurement within the assay file |
All Fields | Material | To describe nanomaterials and small molecules |
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Investigation Title: Nanotechnology Characterization Laboratory (NCL) Dendrimer-Based MRI Contrast Agent
Investigation Description: The objective of this investigation is to characterize a PAMAM dendrimer with an associated gadolinium chelate MRI contrast agent. The nanomaterials submitted for testing at the NCL were (NCL20) G4 tris (hydroxyl) terminated PAMAM dendrimer, (NCL21) G4 pyrrolidinone terminated PAMAM dendrimer, (NCL22) G4.5 COONa terminated PAMAM dendrimer, (NCL23) G4.5 COONa terminated PAMAM dendrimer-Magnevist® complex, (NCL25) G4 tris (hydroxyl) terminated PAMAM dendrimer-Magnevist® complex, and (NCL26) G4 pyrrolidinone terminated PAMAM dendrimer-Magnevist® complex. Commercially available Magnevist® (NCL24) was used as a control. NCL studies addressed in this report can be divided into three main categories: physicochemical characterization; immunotoxicology; in vitro toxicology.
Example Files:
- Investigation File: NCL Dendrimer-Based MRI Contrast Agent (login required)
- Study Files: Size by Dynamic Light Scattering (DLS) | Cytotoxicity Study (login required)
- Material Files: NCL-20 | NCL-21 | NCL-22 | NCL-23 | NCL-24 | NCL-25 | NCL-26 (login required)
- Assay Files: Size by DLS Assay | Lactate Dehydrogenase (LDH) Assay | MTT Assay (login required)
- Report: Dentrimer-Based MRI Image Contrast Agent (login required)
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