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Like ISA-TAB, ISA-TAB-Nano provides fields for entering and referencing terms selected from ontologies and standard terminologies. The ontologies are available at BioPortal (http://www.bioontology.org)

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, which is maintained by the National Center for Biomedical Ontologies. Though the investigator may use alternative ontology and vocabulary sources, the ability to evaluate and share data require that all parties have access to those being used (they should be available to the investigators). All terms and fields used in this standard utilize the NCI EVS (http://evs.nci.nih.gov) and NanoParticle Ontology elements.

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The Table below represents extensions made to each ISA-TAB file in support of ISA-TAB-Nano.

ISA-TAB Extension Field Name

ISA-TAB File

Purpose

Investigation Disease

Investigation

To capture and retrieve investigations associated with specific disease modalities such as cancer

Investigation Disease Term Accession Number

Investigation

To enable semantic interoperability for disease terms

Investigation Disease Term Source REF

Investigation

To enable semantic interoperability for disease terms

Investigation Outcome

Investigation

To enable researchers to review the outcomes of investigations for assessing the utility of the investigation in achieving scientific endpoints

MATERIALInvestigationTo allow for the identification of materials used in the investigation and associated studies
Material File NameInvestigationTo identify the name of the Material File, which lists information about the composition and characteristics of the nanomaterials or other small molecules
Material Source NameInvestigationTo identify the name of the nanomaterial or small molecule associated with the Material File

Study Disease

Investigation

To capture and retrieve studies associated with specific disease modalities such as cancer

Study Disease Term Accession Number

Investigation

To enable semantic interoperability for disease terms

Study Disease Term Source REF

Investigation

To enable semantic interoperability for disease terms

Study Outcome

Investigation

To enable researchers to review the outcomes of studies for assessing the utility of the investigation in achieving scientific endpoints

Study Assay Measurement Name

Investigation

To capture the variables measured in an assay to support cross study analysis

Study Assay Measurement Name Term Accession Number

Investigation

To enable semantic interoperability for assay measurement names

Study Assay Measurement Name Term Source REF

Investigation

To enable semantic interoperability for assay measurement names

Measurement Value

Assay

To record the endpoint value of an assay measurement within the assay file

All Fields

Material

To describe nanomaterials and small molecules

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Investigation Title: Nanotechnology Characterization Laboratory (NCL) Dendrimer-Based MRI Contrast Agent

Investigation Description: The objective of this investigation is to characterize a PAMAM dendrimer with an associated gadolinium chelate MRI contrast agent. The nanomaterials submitted for testing at the NCL were (NCL20) G4 tris (hydroxyl) terminated PAMAM dendrimer, (NCL21) G4 pyrrolidinone terminated PAMAM dendrimer, (NCL22) G4.5 COONa terminated PAMAM dendrimer, (NCL23) G4.5 COONa terminated PAMAM dendrimer-Magnevist® complex, (NCL25) G4 tris (hydroxyl) terminated PAMAM dendrimer-Magnevist® complex, and (NCL26) G4 pyrrolidinone terminated PAMAM dendrimer-Magnevist® complex. Commercially available Magnevist® (NCL24) was used as a control. NCL studies addressed in this report can be divided into three main categories: physicochemical characterization; immunotoxicology; in vitro toxicology.

Example Files:

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