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Managing Sample Composition Annotations | caNanoLab User's Guide| Managing Publications in caNanoLab

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Characterization Characterization

Sample Characterization Overview

Sample Sample characterization describe distinctive characteristics or essential features of the sample determined through analytical methods and records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical by physical or chemical characteristics or characteristics or by data derived under under in vitroand  and in vivo conditions conditions.

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To access characterization functions in the Navigation Tree

1. Click Click Samples and  and Search Existing Samples.
2. Fill in criteria, and click click Search.
3. Click Click Edit in  in the search results.

4. The Navigation Tree appears on the left sidebar and comprises functions which you can use to add annotations to the sample.

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   Understanding the Navigation Tree Abrev Understanding the Navigation Tree Abrev

5. Click Click Characterization. 
   The The All tab  tab displays characterizations already added to the sample by category. Additional tabs show annotations added to the sample for each subcategory.
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• Adding a Physico-chemical Characterization
• Adding an In Vitro Characterization
• Adding an In Vivo Characterization
• Adding an Ex Vivo Characterization
• Adding an Other Ex Vivo

If you have read-only access, you can View a Characterizations Summary.

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Exporting Sample Information to JSON or XML

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PhysicoChemical PhysicoChemical

Adding a AnchorPhysicoChemicalPhysicoChemicalAdding a Physico-Chemical Characterization

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1. Access a sample and characterization.

2. Click the the All tab  tab or the the Physico-Chemical Characterizations tab  tab and click click Add next  next to Physico-chemical Characterization.

3. Both tabs provide customizations based on your your Characterization Type* selection.

4. Follow these steps to fill in the characterization. Links are provided for additional details.

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   AddPhysicoChemical AddPhysicoChemical

   Section	What to Do
   Physico-Chemical Characterization	Fill in the general information about the characterization. Note:  When you are defining the characterization, to select an existing, non-standard Assay Type, select the Characterization Name, other_pc
   Properties	If you select one of the following characterization types, you need to fill in additional properties. Physical State Shape Solubility Surface
   Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
   Finding	Add data findings and supporting documentation relating to the sample. Import as many .csv files as you wish or add derived data manually. Click Add to expand the section, and add data findings and add supporting documents to the characterization.
   Analysis and Conclusion	Enter any relevant analyses and conclusions reached by the data.
   Copy to Other Samples with the Same Primary Organization	Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you are finished, click click Submit to  to save the data to the sample.

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If you selected one of the Characterization Names listed in the following table, the the Properties section  section opens, and you must fill in additional information.

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InVitro InVitro

Adding an In Vitro Characterization

In vitro characterization allows you to add characterizations for the nanomaterial component of the sample derived from analytical techniques performed under under in vitro conditions conditions.

To add an an in vitro characterization characterization

1. Access a sample and characterization.

2. Click the the All tab  tab or the the In Vitro Characterizations tab  tab and click click Add next  next to In Vitro Characterization.

3. Both tabs provide customizations based on your your Characterization Type* selection.

4. Follow these steps to fill in the characterization. Links are provided for additional details.

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   AddInVitroCharacterization AddInVitroCharacterization

   Section	What to Do
   In Vitro Characterization	Fill in the general information about the characterization. Note:  When you are defining the characterization, to select an existing, non-standard Assay Type, select the Characterization Name, other_vt.
   Properties	If you select one of the following characterization names, you need to fill in additional properties. Cytotoxicity Enzyme Induction Transfection
   Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
   Finding	Add data findings and supporting documentation relating to the sample. Import as many .csv files as you wish or add derived data manually. Click Add to expand the section, and add data findings and add supporting documents to the characterization.
   Analysis and Conclusion	Enter any relevant analyses and conclusions reached by the data.
   Copy to Other Samples with the Same Primary Organization	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you are finished, click click Submit to  to save the data to the sample.

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If you selected one of the Characterization Names listed in the following table, the the Properties section  section opens, and you must fill in additional information.

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InVivo InVivo

Adding an In Vivo Characterization

In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under under in vivo conditions conditions.

To add an in vivo characterization

1. Access a sample and characterization.

2. Click the the All tab  tab or the the In Vivo Characterizations tab  tab and click click Add next  next to In Vivo Characterization.

3. Both tabs provide customizations based on your your Characterization Type* selection.

   Follow these steps to fill in the characterization. Links are provided for additional details.

   Section	What to Do
   In Vivo Characterization	Fill in the general information about the characterization. Note:  When you are defining the characterization, to select an existing, non-standard Assay Type, select the Characterization Name, other_vv.
   Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
   Finding	Add data findings and supporting documentation relating to the sample. Import as many .csv files as you wish or add derived data manually. Click Add to expand the section, and add data findings and add supporting documents to the characterization.
   Analysis and Conclusion	Enter any relevant analyses and conclusions reached by the data.
   Copy to Other Samples with the Same Primary Organization	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

4. When you are finished, click click Submit to  to save the data to the sample.

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1. Access a sample and characterization.

2. Click the the All tab  tab or the the Ex Vivo Characterizations tab  tab and click click Add next  next to Ex Vivo Characterization.

3. Both tabs provide customizations based on your your Characterization Type* selection.

   Follow these steps to fill in the characterization. Links are provided for additional details.

   Section	What to Do
   Ex Vivo Characterization	Fill in the general information about the characterization. Note:  When you are defining the characterization,

   to

   to select an existing, non-standard Assay Type, select the Characterization Name, other_ex_vv
   Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
   Finding	Add data findings and supporting documentation relating to the sample. Import as many .csv files as you wish or add derived data manually. Click Add to expand the section, and add data findings and add supporting documents to the characterization.
   Analysis and Conclusion	Enter any relevant analyses and conclusions reached by the data.
   Copy to Other Samples with the Same Primary Organization	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

4. When you are finished, click click Submit to  to save the data to the sample.

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1. Access a sample and characterization.

2. Click the the All tab  tab or the the Other Ex Vivo Characterizations tab  tab and click click Add next  next to Ex Vivo Characterization.

3. Both tabs provide customizations based on your your Characterization Type* selection.

   Follow these steps to fill in the characterization. Links are provided for additional details.

   Section	What to Do
   Other Ex Vivo Characterization	Fill in the general information about the characterization.
   Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
   Finding	Add data findings and supporting documentation relating to the sample. Import as many .csv files as you wish or add derived data manually. Click Add to expand the section, and add data findings and add supporting documents to the characterization.
   Analysis and Conclusion	Enter any relevant analyses and conclusions reached by the data.
   Copy to Other Samples with the Same Primary Organization	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

4. When you are finished, click click Submit to  to save the data to the sample.

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When you are adding a characterization, fill in the following characterization information.

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DesignMethods DesignMethods

Defining Characterization Design and Methods

When you are adding a characterization, fill in the following design, methods, and techniques used.

When you are finished, click click Save or  or Cancel to  to close the section without saving.

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Finding Finding

Adding Data Findings to a Characterization

To add findings to a characterization, you can add data directly to Data and Conditions by creating columns and adding data manually or you can import as many .csv files as needed. Information can include include laboratory conditions, pH, or temperature. You  You can add as many files as you wish.

1. Add data values to Data and Conditions.
   
   1. To import a file of data values
      1. Save the spreadsheet of data values to a csv (comma-separated value) file.
      2. Click Click Import csv and  and select and follow the prompts to add the data file to the Findings Info.
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      3. The columns and data are added to Data and Conditions.
   2. To add the data values manually
      1. Specify the number of columns and  columns and rows for  for the matrix, and click click Update.
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      2. Add the data values to the rows.
         
         

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   Whether you imported or added information manually, you can preface each data value with one of the following: Maintain the default, equal to (=), or select greater than (>), less than (<), or infinity (approximate). Image Modified

2. To define a column, click an underlined column heading.
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   The Column Definition panel displays.
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3. Select a a Column Type, Datum or Condition.

4. Select a Column  Column Name or select  or select other and  and add a new one.

   Info
   title Column Notes
   You can add up to three cell viability Column Names, including cell viability, cell viability B, and cell viability C. You can further identify the column with the Column Value Type.

   
   

   1. For Column Type, Datum, the following characterization(s) display customized customized Column Name options options.

      Characterization Type	Column Type and Column Name Option(s)
      Physico-Chemical	Molecular – Molecular Weight Purity – % purity for sample Relaxivity – R1, R2, T1, T2 Size – PD1, Peak N , RMS size, Z Average Surface – charge, zeta potential
      In Vitro	Enzyme Induction – % of Control
      In Vivo	Click Other to name the column yourself.

   2. For Column Type, Condition, all characterizations provide the the Column Name options  options in the left column of the following table. The Column Name autopopulates the the Condition Property Property options in the right column.

      Column Type, Condition Autopopulates Column Name	Column Name Autopopulates Condition Property
      Centrifugation	N/A
      Culture Media	media type, serum percentage
      Electromagnetic Radiation	bandwidth, frequency, time, wavelength
      Freeze Thaw	N/A
      Long Term Storage	lyophilized, time
      Lyophilization	time
      pH	N/A
      Sample concentration	N/A
      Short Term Storage	lyophilized, time
      Solvent Media	ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
      Sonication	number of pulses, pulse duration
      Temperature	N/A

5. To further identify a column, select a a Column Value Type.

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   Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).

6. Select a a Column Value Unit, or select select other and  and add one.

7. If you want the same value to fill all rows in a column, add a a Constant Value.

   Info
   title For Column Value Type, boolean
   For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.

8. Click Click Save, and the column(s) are updated.
   

   Info
   If needed, click Set Column Order to change the order of the column headings in the matrix.

   
   

9. Click Click Save in  in the Finding section.
   

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1. In the Finding section of the characterization, next to to Files, click  click Add.
2. Upload, browse, and select the file or enter the file's URL where the document is located.
3. Complete the following.
   
   1. Select the File  File Type (required), Document, Graph, Image, Movie, or Spreadsheet.
   2. Enter the File  File Title (required).
   3. Specify Keywords to  Keywords to associate with the file
   4. Enter a Description of  Description of additional information of the file.

4. Click Submit to  Submit to add the file(s) to the sample.

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CopyingCharacterizations CopyingCharacterizations

Copying to Samples in the Same Primary Organization

The composition files and/or derived data for a sample can be copied to other samples from the same primary point of contact.

1. From the the All tab tab's characterizations summary, click click Edit at  at the right of a characterization section.
2. The Characterization opens and at the bottom of the page, in the the Copy to other samples... section section, select one or more samples with the same primary point of contact.
3. Click Click Also copy finding data and conditions?.

4. Click Click Submit to  to copy the characterization.

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Managing Sample Composition Annotations | caNanoLab User's Guide| Managing Publications in caNanoLab