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Nanotechnology is being applied to clinical therapeutics, but this use case could be extended to development of any specialized therapeutics. There are various pre-existing databases holding experimental data that need to be accessible across the entire community to facilitate rational nanomaterial design. Two strategies are being employed. The first is to establish semantic interoperability by finding areas of semantic overlap in the current database models based on controlled vocabularies (NCI Thesaurus, NCI Metathesaurus, Nanoparticle Ontology). The second is to develop a data submission standard based on the extension of standardized models (Biomedical Research Integrated Domain Group (BRIDG), Life Sciences Domain Analysis Model (LS-DAM)) where extensions are supported by controlled vocabularies. New vocabulary is needed to support both of these strategies. New concepts are curated in the controlled vocabularies as appropriate and term definitions are reviewed by the community.
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