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Thus it is assumed that Semantic Infrastructure 2.0 subsumes the scope of the current caBIG®-CBIIT semantic infrastructure including caDSR and EVS. In particular, the Semantic Infrastructure 2.0 is expected to support relevant aspects of both informational ("static") and behaviorial behavioral ("dynamic") metadata in addition to historical terminology and value-set management functions.

It is especially important to note that the support for informational, behaviorialbehavioral, and terminology and value-set management will be integrated with the caGrid 2.0 infrastructure to allow for both design-time and run-time support for CSI at the level of individual services deployed on caGrid 2.0.

Critical aspects of the overarching framework for integration of the Semantic Infrastructure 2.0 with the caGRID caGrid 2.0 technical infrastructure are expected to emerge during evolution of both this document and the caGrid 2.0 Roadmap. Ultimately these aspects will be harmonized and unified in a single technical approach. The integration will be significantly deeper than the current integration as supported by the Global Message Index Model Exchange (GMIGME).

The Semantic Infrastructure 2.0 Roadmap is being developed in a transparent, collaborative process with the caBIG® community to ensure that the relevant requirements needed to provide the planned design- and run-time support for informational and behavioral semantics integrated with the caGrid 2.0 infrastructure are appropriately surfaced and defined. The overarching enterprise-level requirement for both the Semantic Infrastructure and caGrid 2.0 projects is to provide comprehensive support for the information discovery and integration, and functional coordination requirements, that will meet the evolving needs of the scientists, clinicians, patients and other stakeholders who collectively define the caBIG® community.

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With respect to the overarching technology strategies being adopted to guide the development of Semantic Infrastructure 2.0, there are several "givens:"

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Both the Semantic Infrastructure 2.0 and caGrid 2.0 will be developed and deployed within the context of an overarching approach to enterprise architecture which uses the distributed computing design paradigm commonly referred to as Service-Oriented Architecture (SOA). In addition, because of the fundamental importance of semantics in any architecture approach in the context of the life sciences and healthcare (in the broadest sense of those terms), the SOA being developed by NCI CBIIT as manifested in the Semantic Infrastructure 2.0 and caGRID caGrid 2.0, is referred to as a "semantically-aware SOA" (sSOA). It is beyond the scope of this document to discuss in detail the various benefits and goals, core organizing motivations, or fundamental design principles of SOA. However, the following bullet points summarize each of these topics. Interested readers can refer to a number of references including two texts by Thomas Erl: "Principles of Service Design" and "SOA Design Patterns."

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The Semantic Infrastructure 2.0 is in large part the operational support for the metadata defined in the CBIIT implementation guide for the HL7 Services-Aware Interoperability Framework (SAIF). Readers interested in the specifics of the metadata defined by the CBIIT SAIF implementation guide should consult that document directly httphttps://wiki.nci.xxx.xxxnih.gov/x/fldyAQ. In particular, the chapter on the Enterprise Conformance and Compliance Framework (ECCF) provides focal point for the definition and representation of the collective set of informational and behavioral metadata which the Semantic Infrastructure 2.0 will support at both design- and run-time (via the caGrid 2.0 platform.)

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The project to define the Roadmap for version 2 of the caBIG® semantic infrastructure, that is, the "next generation" of the current caDSR and EVS semantic infrastructure is being conducted in parallel with and is fundamentally coordinated with the caGrid 2.0 Roadmap project. The ultimate goal of the two efforts is to produce two complementary but integrated Roadmaps that will enable caGrid 2.0 to provide expanded semantic processing capabilities (when required) including but not limited to run-time service discovery and resolution of semantic queries. Details of both the Semantic Infrastructure 2.0 Roadmap and the caGrid 2.0 Roadmap, will be publicly available and open for community input.

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