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NCI Thesaurus (NCIt) (download) is NCI's reference terminology and ontology. NCIt provides the responsive, science-based terminology concepts used in caCORE and caBIG to establish data semanticsNCI semantic infrastructure and information systems. It covers terminology for clinical care, translational and basic research, and public information and administrative activities. NCIt is also a widely recognized standard for biomedical coding and reference, used by a broad variety of public and private partners both nationally and internationally.

NCIt content comes from NCI, partners , NIH, agencies and standards development organizations such as FDA and CDISC, caBIG and other groupspartners, user requests, and an ongoing review of the open literaturescientific literature (see EVS Use and Collaborations). This content is organized in a richly structured description logic environment, with more than 200400,000 relationships between concepts to help define and connect them. Individual concepts include codes, terms, abbreviations, synonyms, definitions, links to outside sources, and a wide variety of other useful information.

The NCI Thesaurus is updated monthly. The differences between one month's release and the next are summarized on the NCI EVS list server. API access to the complete history of every concept in the Thesaurus is supported in caCORE EVS 3.2 and EVS/caCORE 4.x. Real-time access to the complete history of every concept provides NCI Thesaurus users with the capability to deal with change over time due to the way that information is coded or classified. 

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