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NCIt content comes from NCI, NIH, agencies and standards development organizations such as FDA and CDISC, other partners, user requests, and ongoing review of the scientific literature (see EVS Use and Collaborations). This content is organized in a richly structured description logic environment, with more than 400,000 relationships between concepts to help define and connect them. Individual concepts include codes, terms, abbreviations, synonyms, definitions, links to outside sources, and a wide variety of other useful information.

More complete description of the semantics of NCIt is available. A document briefly describing the editorial policies governing change to NCIt content is included with the semantics information.

The NCI Thesaurus is updated monthly, averaging roughly 700 new concept and many additional changes with each release.  Complete change history for each concept is provided through EVS APIs and browsers. 

NCIt is registered in the HL7 OID Registry

NCIt provides the central organizing backbone cross-links and semantics for a broader range of EVS terminology resources. NCIt is the lead reference point for the NCI Metathesaurus (NCIm), which provides rich synonymy and mappings among the codes and terms used in more than 70 biomedical terminologies.  EVS browsers and servers provide access cross-links NCIt and NCIm to a wide variety of other terminologies and ontologies that are published separately, such as CTCAE, GO, ICD-9-CM, LOINC, MedDRA, SNOMED CT, and the VA's NDF-RT.

Semantics of NCIt

NCIt provides four features which together provide proven sufficient basis for the semantic integration of the caCORE. These four features are:

• Permanent, non-semantic concept codes
• NCI preferred terms for each concept
• English language definitions
• Synonyms

More complete description of the semantics of NCIt is available. A document briefly describing the editorial policies governing change to NCIt content is included with the semantics information. 

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