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Version B. As above, except globally sequence all genes. [ Science 321: 1807-1812 (2008) (Posted for workgroup members). Delete steps 1 and 2 and replace step 3 with: 3) Develop a gene model for each of the genes in the Human genome.

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This is a scenario based on evaluating and enriching the NanoParticle Ontology (NPO) (posted for the workgroup The NanoParticle Ontoloty Ontology (posted for the workgroup) is an ontology which is being developed at Washington University in St. Louis to serve as a reference source of controlled vocabularies and terminologies in cancer nanotechnology research. Concepts in the NPO have their instances in the data represented in a database or in literature. In a database, these instances include field names, field entries, or both for the data model. NPO represents the knowledge supporting unambiguous annotation and semantic interpretation of data in a database or in the literature. To expedite the development of NPO, object models must be developed to capture the concepts and inter-concept relationships from the literature. Minimum information standards should provide guidelines for developing these object models, so the minimum information is also captured for representation in the NPO.

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