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The problem is that repositories are often not flexible enough to store data that do not conform to known standards. Genomics, for example, benefits from community genomics standards groups and open industry standards. Many other fields of study are without such standards, yet generate significant amounts of data, without a standard way to store it that would make the data more accessible, easily accessed, and potentially reused by the research community.

The Center for Strategic Scientific Initiatives Data Coordinating Center (CSSI DCC) stores and manages access to data generated in support of cancer research funded or supported by the CSSI. Frederick National Lab, under the leadership of Andrew Quong, developed the CSSI DCC Portal, a repository for CSSI DCC data and also emerging data types without a standard approach to data storage. The data currently in the DCC conform to the standard Investigation-Study-Assay tab-delimited format (ISA-TAB) format, which describes a scientific investigation, its study or studies, and each study's assay(s).

The DCC's goal is to use the CSSI DCC Portal to store emerging data types in addition to ISA-TAB. Facilitating this is the DCC's design approach, which follows FAIR principles for scientific data management and stewardship--Findable, Accessible, Interoperable, and Reusable, applied metadata standards, and involved interactions with the academic research community to seek out and apply their best practices.

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