 |
Page History
...
| Note | ||
|---|---|---|
| ||
However, part of the Infrastructure Inception activities include Prototyping Orchestrations and/or Choreographies (including Life Science workflows) as well as outreach to community to address other major use cases and requirements. The life sciences communities are engaged with the Roadmap inception efforts now .on the following: Lymphoma "workflow" use cases and requirements The use cases and requirements gathering described above being outlined and written in draft activities are the at links above and will be migrated to relevant sections in the Roadmaps when mature as use cases, requirements and resulting architecture design. |
Discovering a biomarker
A scientist is trying to identify a new genetic biomarker for HER2/neu negative stage I breast cancer patients. Using a caGrid-aware client, the scientist queries for HER2/neu negative tissue specimens of Stage I breast cancer patients at LCCC (University of North Carolina Lineberger Comprehensive Cancer Center-NC Cancer Hospital) that also have corresponding microarray experiments. Analysis of the microarray experiments identify genes that are significantly over-expressed and under-expressed in a number of cases. The scientist decides that these results are significant, and related literature suggest a hypothesis that gene A may serve as a biomarker in HER2/neu negative Stage I breast cancer. To validate this hypothesis in a significant number of cases the scientist needs a larger data set, so the scientist queries for all the HER2/neu negative specimens of Stage I breast cancer patients with corresponding microarray data and also for appropriate control data from other cancer centers. After retrieving the microarray experiments the scientist analyzes the data for over-expression of genes A.
...
