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The meeting Date is hyperlinked to the notes and hyperlinks in the Executive Summary are for specific presentations
Amnon Shabo (slides on request email@example.com) spoke about the HL7 Clinical Gemonics Work Group - From Healthcare to Research.
Mike Hucka (slides on request firstname.lastname@example.org) from Caltech spoke about SBML (Systems Biology Markup Language) as an open community standard initiative. SBML is a representation format, based on XML, for communicating and storing computational models of biological processes. Mike reviewed past, present and future directions for the community and provided lessons learned – what went right (involved actual stakeholders, addressed real needs -not perceived ones, transparent and inclusive process, etc.) and where there were challenges (testing, complexity creep, not formalizing processes sufficiently).
Cecilia Neomi Arighi (PROICR_Arighi_2011.pdf) from U of Delaware presented on Protein Ontology. (PRO) provides the ontological representation of proteins and protein complexes and shows the relationships between them. It encompasses three sub-ontologies: proteins based on evolutionary relatedness (ProEvo); protein forms produced from a given gene locus (ProForm); and protein-containing complexes (ProComp). There is a website with extensive browse and search capabilities and includes additional annotations using other ontologies like Pfam and GO.
John Speakman (Speakman_CTMS_Program_Status_Futures_20110608 Final_508.ppt), NCI CBIIT CPO kicked-off the workspace call with a caBIG Program Update. Mike Smoot (caBIG_Cytoscape_talk_6-8-2011.pdf), UCSD, is lead developer for Cytoscape. He provided an overview of the Cytoscape software platform for visualizing molecular interactions and pathways and integrating these with annotations and data. His talk also focused on the active Cytoscape community.
Mark Bray (2011_05_18_CaBIGdraft.ppt in the archive) from the Broad Institute gave a presentation on CellProfiler. It is a tool which integrates various algorithms. It is capable of extracting measurements for every individual cell in an image-based screen, ranging from standard assays (e.g., cell count, size, per-cell protein levels) as well as more complex morphological assays (e.g., cell/organelle shape or subcellular patterns of DNA or protein staining).
The ICR workspace heard reports on the recent BioIT and AACR meetings from Mark Adams (BAH) and Jens Poschet (Sapient) respectively.
The ICR participants presented on their assigned projects.
Alex Kanous (ICR+DSIC+032311.ppt) from the DSIC Knowledge Center provided a presentation on the electronic Data Use Agreement tool. The tool may be used for generating DUAs for outgoing data based on a catalog of standardized, modular contract clauses, each of which corresponds to one of the E-DSSF’s sensitivity ratings.
Anton Nekrutenko (Galaxy.pdf) and Daniel Blankenberg and of The Pennsylvania State University gave a presentation on Galaxy, an open-source next generation sequence (NGS) analysis software system. It addresses the need to empower the scientists without access to extensive infrastructure to do the analysis. Galaxy is a free web service, and has a plethora of analysis tools and has workflow generation capabilities
caArray Users Meeting (ICR_WS_Meeting_2011_02_09.pptx on SVN) featured upcoming plugin architecture for support the addition of new parsers and data storage mechanisms.
Jenny Kelley (caLIMSv2Update_ICR_26Jan11_final.pptx), NCI Population Sciences, updated the community on caLIMS v2 new features. She also provided a thorough demonstration of the tool.
The ICR Workspace is hearing reports on activities for the last period.