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A major barrier to the conduct of biomedical research is how difficult it is to share biomedical research data, both within and between institutions. Data located in different data repositories are almost always organized, categorized, and represented in different ways. This problem has been referred to as “the Chasm of Semantic Despair.”  In an attempt to address this problem, the Cancer Informatics group at the NCI, in collaboration with their colleagues at the FDA, ISO, HL7, and CDISC, developed a new international standard data model for biomedical research called the Biomedical Research Integrated Doman Domain Group (BRIDG) model.  The purpose of the BRIDG model is to “bridge” the large number of Chasms of Semantic despair that exist both within and between academic medical centers, pharmaceutical companies, and government regulators. The Sidney Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, has successfully designed and implemented a cancer research information system based on the NCI-BRIDG model. In this talk. Dr. Klumpp will describe how the BRIDG model has been implemented in the cancer research information system at Thomas Jefferson and the benefits of such an integrated system.

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