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ISA-TAB-Nano Introduction
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The ISA-TAB-Nano specification is intended to facilitate the submission and exchange of nanomaterial descriptions and characterization data (metadata and summary data) along with the other files (raw/derived data files, image files, protocol documents, etc.) among individual researchers and to/from nanotechnology resources like the NCI’s cancer Nanotechnology Laboratory (caNanoLab) portal and the Nanomaterial-Biological Interactions (NBI) knowledgebase
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The ISA-TAB-Nano project is an effort of the National Cancer Institute (NCI) National Cancer Informatics Program (NCIP) Nanotechnology Informatics Working Group (Nano WG).
ISA-TAB-Nano Standards Re-Use
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The ISA-TAB-Nano format specification is based on an existing specification developed by the ISA-commmunity
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Like ISA-TAB, ISA-TAB-Nano provides fields for entering and referencing terms selected from ontologies and standard terminologies. The ontologies are available at BioPortal
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The Table below represents extensions made to each ISA-TAB file in support of ISA-TAB-Nano.
ISA-TAB Extension Field Name | ISA-TAB File | Purpose |
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Investigation Disease | Investigation | To capture and retrieve investigations associated with specific disease modalities such as cancer |
Investigation Disease Term Accession Number | Investigation | To enable semantic interoperability for disease terms |
Investigation Disease Term Source REF | Investigation | To enable semantic interoperability for disease terms |
Investigation Outcome | Investigation | To enable researchers to review the outcomes of investigations for assessing the utility of the investigation in achieving scientific endpoints |
MATERIAL | Investigation | To allow for the identification of materials used in the investigation and associated studies |
Material File Name | Investigation | To identify the name of the Material File, which lists information about the composition and characteristics of the nanomaterials or other small molecules |
Material Source Name | Investigation | To identify the name of the nanomaterial or small molecule associated with the Material File |
Study Disease | Investigation | To capture and retrieve studies associated with specific disease modalities such as cancer |
Study Disease Term Accession Number | Investigation | To enable semantic interoperability for disease terms |
Study Disease Term Source REF | Investigation | To enable semantic interoperability for disease terms |
Study Outcome | Investigation | To enable researchers to review the outcomes of studies for assessing the utility of the investigation in achieving scientific endpoints |
Study Assay Measurement Name | Investigation | To capture the variables measured in an assay to support cross study analysis |
Study Assay Measurement Name Term Accession Number | Investigation | To enable semantic interoperability for assay measurement names |
Study Assay Measurement Name Term Source REF | Investigation | To enable semantic interoperability for assay measurement names |
Measurement Value | Assay | To record the endpoint value of an assay measurement within the assay file |
All Fields | Material | To describe nanomaterials and small molecules |
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ISA-TAB-Nano File Structure
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Once the ISA-TAB-Nano files have been created, the files can be validated and submitted into nanotechnology resources that support the ISA-TAB-Nano specification. It is anticipated that validation of the files may occur via a validation service that leverages a modified version of the ISA-TAB validator
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It is also anticipated that nanotechnology resources like caNanoLab (https://cananolab.nci.nih.gov/caNanoLab/ ), the Nanomaterial-Biological Interactions (NBI) knowledgebase
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ISA-TAB-Nano Curated Examples Include Page